Platelet chemokines in health and disease
E Karshovska1, C Weber, P von Hundelshausen
1Philipp von Hundelshausen, MD, Institute for Cardiovascular Prevention, Ludwig-Maximilians University (LMU) Munich, Pettenkoferstr. 9, 80336 Munich, Germany, Tel.: +49 89 5160 4359, Fax: +49 89 5160 4352,
Abstract:
In recent years, it has become clear that platelets and platelet-derived chemokines, beyond their role in thrombosis and haemostasis, are important mediators affecting a broad spectrum of (patho)physiological conditions. These biologically active proteins are released from α-granules upon platelet activation, most probably even during physiological conditions. In this review, we give a concise overview and an update on the current understanding of platelet-derived chemokines in a context of health and disease.
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