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Combinatorial temporal patterning in progenitors expands neural diversity.

Omer Ali Bayraktar¹, Chris Q Doe

¹Howard Hughes Medical Institute, University of Oregon, Eugene, Oregon 97403, USA.

|June 21, 2013

Summary

This summary is machine-generated.

Drosophila intermediate neural progenitors (INPs) sequentially produce distinct neural subtypes by expressing specific transcription factors. This temporal patterning, alongside parental neuroblast activity, increases neural diversity in the adult central complex.

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Area of Science:

Developmental biology
Neuroscience
Genetics

Background:

Human outer subventricular zone (OSVZ) neural progenitors and Drosophila type II neuroblasts generate intermediate neural progenitors (INPs).
The role of INPs in diversifying neural cell types remains unclear.

Purpose of the Study:

To investigate whether INPs expand or diversify neural cell types.
To identify the mechanisms underlying neural diversity generation in Drosophila and potentially in humans.

Main Methods:

Analysis of gene expression and progeny in Drosophila type II neuroblast lineages.
Functional studies of transcription factors Dichaete, Grainy head, and Eyeless in INPs.

Main Results:

Drosophila INPs sequentially produce distinct neural subtypes.
Sequential expression of Dichaete, Grainy head, and Eyeless transcription factors is required for subtype production.
Parental type II neuroblasts also exhibit temporal patterning, generating diverse neuronal/glial progeny.

Conclusions:

Temporal patterning in both neuroblasts and INPs collaborates to enhance neural diversity in the adult central complex.
Similar mechanisms may be employed by OSVZ progenitors in the human brain to increase neural diversity.