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Two atypical cases of Kingella kingae invasive infection with concomitant human rhinovirus infection

Romain Basmaci1, Brice Ilharreborde, Catherine Doit

  • 1Université Paris Diderot, Sorbonne Paris Cité, Paris, France.

Journal of Clinical Microbiology
|June 21, 2013
PubMed

Insights

Two children with atypical Kingella kingae infections, presenting as soft tissue and femoral Brodie abscesses, were diagnosed using PCR. Both cases showed a co-infection with human rhinovirus, highlighting unusual presentations of K. kingae.

Area of Science:

  • Pediatric infectious diseases
  • Microbiology
  • Molecular diagnostics

Background:

  • Kingella kingae is an increasingly recognized cause of invasive pediatric infections, often presenting with osteoarticular manifestations.
  • Atypical presentations of K. kingae infections can pose diagnostic challenges.

Observation:

  • Two children presented with unusual K. kingae infections: a soft tissue abscess and a femoral Brodie abscess.
  • Both patients were co-infected with human rhinovirus, detected concurrently with K. kingae.

Findings:

  • Polymerase chain reaction (PCR) was crucial for diagnosing K. kingae in these atypical cases.
  • Multilocus sequence typing and rtxA sequencing were used to characterize the K. kingae strains isolated from oropharyngeal swabs.

Implications:

  • This study expands the spectrum of K. kingae manifestations in children.
  • The frequent co-occurrence with human rhinovirus warrants further investigation into potential synergistic or contributing roles in K. kingae pathogenesis.
  • Enhanced diagnostic approaches, including PCR, are vital for identifying K. kingae in complex pediatric infections.

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