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Chemistry and pharmacology of 4-hydroxylonchocarpin: a review
Victor Kuete1, Jaures A K Noumedem, Frederic Nana
1Department of Biochemistry, Faculty of Science, University of Dschang, Yaounde, Cameroon. kuetevictor@yahoo.fr
Abstract:
4-hydroxylonchocarpin (LCP) or 2',4-dihydroxy-3',4'-(2,2-dimethylchromene) chalcone is a chalcone of the class flavonoid, with a molecular weight of 322 g/mol mostly isolated in the family Moraceae and Leguminosae. LCP was reported to have a variety of pharmacological activities such as antibacterial, antifungal, anticancer, anti-reverse transcriptase, antitubercular, antimalarial, anti-inflammatory, ornitnine decarboxylase activity and antioxidant. The hemisynthesis of the compound has been described. The present review was undertaken to bring out together the knowledge on LCP, and can serve as the start point for future research and valorization accomplishments.
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