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Updated: May 10, 2026

Synthesis of a Water-soluble Metal–Organic Complex Array
Published on: October 8, 2016
Pattern recognition analysis in complex molecule synthesis and the preparation of iso-Diels-Alder motifs
Feng Peng1, Robin E Grote, Rebecca M Wilson
1Chemistry Department, Columbia University, New York, NY 10027, USA.
Abstract:
The identification of synthesizable substructural domains within more complex structural targets is of significant value in designing a workable plan of synthesis. We term this process "pattern recognition analysis" (PRA). In this paper we continued to build on the theme of PRA as a potential resource in retrosynthetic blueprints to reach highly challenging targets. The paper operates at two levels. First, there is provided a clear sense of definitions of categories by which patterns are related to hypothetical reaction types. Although the required reaction type may for the moment not exist, we believe that this method of analysis is likely to promote innovation that identifies unmet needs and opportunities to advance the cause of complex target synthesis. In addition, we describe reductions to practice in expanding the menu of achievable patterns. It is likely that the future value of PRA will be associated with its utility in leading the way to new and exploitable chemical innovation.
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