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Injectable autogenous corium: technique development in the rat model.

B P Andersen1, A E Stefani

  • 1Division of Plastic Surgery, Mount Carmel Mercy Hospital, Detroit, MI 48235.

Annals of Plastic Surgery
|July 1, 1990
PubMed
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Injectable autogenous collagen derived from coarse dermal homogenates persisted longer in rats than fine homogenates. This research explores new methods for dermal filler longevity.

Area of Science:

  • Biomaterials Science
  • Dermatology
  • Tissue Engineering

Background:

  • Injectable bovine collagen is a common treatment for facial rhytides.
  • The use of injectable autogenous collagen for cosmetic purposes has not been previously reported.
  • Investigating autologous materials offers potential for improved biocompatibility and reduced allergic reactions.

Purpose of the Study:

  • To evaluate the persistence of injectable autogenous collagen prepared using different homogenization techniques.
  • To compare the efficacy of fine versus coarse dermal homogenates as injectable implants in a rat model.

Main Methods:

  • Dermal tissue from rats was processed using commercial tissue homogenizers (fine emulsification) and a household blender (coarse homogenates).
  • The prepared autogenous collagen implants were injected into rats.

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  • Serial clinical and histological examinations were performed to assess implant persistence and resorption over time.

    • Main Results:

    • Fine emulsification using commercial homogenizers resulted in implants that were largely resorbed.
    • Coarse homogenates produced by a household blender persisted for 5 to 6 months, although eventual resorption occurred.
    • Dermal implants prepared via coarse homogenization demonstrated significantly longer persistence compared to fine homogenates.

    Conclusions:

    • Coarse homogenates of dermis exhibit greater longevity as injectable implants compared to fine homogenates in the rat model.
    • Homogenization technique significantly influences the resorption rate and persistence of autogenous dermal implants.
    • These findings suggest that optimizing the preparation method of autogenous collagen could enhance the duration of effect for dermal fillers.