Related Experiment Video
Updated: May 10, 2026

Tailoring In Vivo Cytotoxicity Assays to Study Immunodominance in Tumor-specific CD8+ T Cell Responses
Published on: May 6, 2019
"License to kill" reflects joint action of CD4 and CD8 T cells
1ISA Pharmaceuticals and Leiden University Medical Center, Leiden, the Netherlands. cmelief@lumc.nl
Abstract:
The spontaneous T-cell responses to the KIF20A cancer-associated antigen found by Tomita and colleagues among peripheral blood mononuclear cells of patients with cancer, but not healthy people, involve both CD4 and CD8 T cells. Synthetic long peptides of KIF20A stimulate synergy between these two T-cell types to promote cancer cell killing.
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