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Related Concept Videos

Pedigree Analysis01:35

Pedigree Analysis

Overview
Pedigree Analysis01:35

Pedigree Analysis

Overview
Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
Incomplete Dominance01:43

Incomplete Dominance

Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.
Non-nuclear Inheritance01:29

Non-nuclear Inheritance

Most DNA resides in the nucleus of a cell. However, some organelles in the cell cytoplasm⁠—such as chloroplasts and mitochondria⁠—also have their own DNA. These organelles replicate their DNA independently of the nuclear DNA of the cell in which they reside. Non-nuclear inheritance describes the inheritance of genes from structures other than the nucleus.
Non-nuclear Inheritance01:29

Non-nuclear Inheritance

Most DNA resides in the nucleus of a cell. However, some organelles in the cell cytoplasm⁠—such as chloroplasts and mitochondria⁠—also have their own DNA. These organelles replicate their DNA independently of the nuclear DNA of the cell in which they reside. Non-nuclear inheritance describes the inheritance of genes from structures other than the nucleus.

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Related Experiment Video

Updated: May 10, 2026

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
09:37

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

Published on: August 15, 2019

Digenic inheritance in medical genetics.

Alejandro A Schäffer

    Journal of Medical Genetics
    |June 21, 2013
    PubMed
    Summary
    This summary is machine-generated.

    Digenic inheritance (DI) is the simplest genetic model for complex diseases. Combining high-throughput sequencing with protein-protein interaction networks can accelerate the discovery of DI, improving our understanding of genetic disease.

    Keywords:
    Digenic inheritanceepistatisfacioscapulohumeral muscular dystrophyhigh-throughput sequencingprotein-protein interactions

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    Area of Science:

    • Genetics
    • Genomics
    • Molecular Biology

    Background:

    • Digenic inheritance (DI) is the simplest genetic model for complex diseases, yet few human phenotypes are linked to it.
    • High-throughput sequencing (HTS) offers potential for identifying DI by simultaneously detecting mutations in two genes.

    Purpose of the Study:

    • To review and characterize existing examples of human DI.
    • To identify trends and challenges in DI research.
    • To propose strategies for improving DI discovery.

    Main Methods:

    • Systematic literature review of human DI cases.
    • Analysis of evidence types, including genetic linkage, candidate genes, and protein-protein interactions (PPIs).
    • Evaluation of the role of HTS in DI identification.

    Main Results:

    • Most successful DI discoveries utilized knowledge of candidate genes and PPIs.
    • Positional genetic linkage analysis has been largely unsuccessful for DI.
    • HTS has been underutilized in DI research, with limited examples found before 2012.

    Conclusions:

    • Knowledge of candidate genes and PPIs are crucial for DI discovery.
    • Integrating HTS with PPI networks is a promising strategy for future DI research.
    • Further development of methods combining HTS and PPI data could expedite the identification and validation of DI.