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The impact of chimerism in DNA-based forensic sex determination analysis
Renjith George1, Preethy Mary Donald, Sumanth Kumbargere Nagraj
1Department of Oral Medicine, Oral Diagnosis and Oral Pathology, Faculty of Dentistry, Melaka Manipal Medical College, 75150 Melaka, Malaysia.
Abstract:
Sex determination is the most important step in personal identification in forensic investigations. DNA-based sex determination analysis is comparatively more reliable than the other conventional methods of sex determination analysis. Advanced technology like real-time polymerase chain reaction (PCR) offers accurate and reproducible results and is at the level of legal acceptance. But still there are situations like chimerism where an individual possess both male and female specific factors together in their body. Sex determination analysis in such cases can give erroneous results. This paper discusses the phenomenon of chimerism and its impact on sex determination analysis in forensic investigations.
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