Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Nucleic acids

Nucleic acids

Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes, the...

Nucleic Acids

Nucleic Acids

Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes, the...

RNA-seq

RNA-seq

RNA sequencing, or RNA-Seq, is a high-throughput sequencing technology used to study the transcriptome of a cell. Transcriptomics helps to interpret the functional elements of a genome and identify the molecular constituents of an organism. Additionally, it also helps in understanding the development of an organism and the occurrence of diseases.
Before the discovery of RNA-seq, microarray-based methods and Sanger sequencing were used for transcriptome analysis. However, while microarray-based...

Types of RNA

Types of RNA

Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...

Types of RNA

Types of RNA

Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...

Types of RNA

Types of RNA

Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Correction: Creation of a pandemic memory by tracing COVID-19 infections and immunity in Luxembourg (CON-VINCE).

BMC infectious diseases·2025

Same author

Dopamine Pathway and Parkinson's Risk Variants Are Associated with Levodopa-Induced Dyskinesia.

Movement disorders : official journal of the Movement Disorder Society·2024

Same author

Comprehensive blood metabolomics profiling of Parkinson's disease reveals coordinated alterations in xanthine metabolism.

NPJ Parkinson's disease·2024

Same author

Creation of a pandemic memory by tracing COVID-19 infections and immunity in Luxembourg (CON-VINCE).

BMC infectious diseases·2024

Same author

Early-to-mid stage idiopathic Parkinson's disease shows enhanced cytotoxicity and differentiation in CD8 T-cells in females.

Nature communications·2023

Same author

Dopamine pathway and Parkinson's risk variants are associated with levodopa-induced dyskinesia.

medRxiv : the preprint server for health sciences·2023

Search research articles

Related Experiment Video

Updated: May 10, 2026

Identification of Circular RNAs using RNA Sequencing

Identification of Circular RNAs using RNA Sequencing

Published on: November 14, 2019

The complexity, function and applications of RNA in circulation.

Alton Etheridge¹, Clarissa P C Gomes, Rinaldo W Pereira

¹Pacific Northwest Diabetes Research Institute, Seattle WA, USA.

Frontiers in Genetics

|June 21, 2013

Summary

Extracellular RNA molecules found in blood circulation are stable and originate from various sources. Research is exploring their functions and potential applications.

Keywords:

cell–cell communication exogenous RNA exosomes microRNA microvesicles

More Related Videos

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions

Published on: October 21, 2022

Related Experiment Videos

Last Updated: May 10, 2026

Identification of Circular RNAs using RNA Sequencing

Identification of Circular RNAs using RNA Sequencing

Published on: November 14, 2019

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions

Published on: October 21, 2022

Area of Science:

Biochemistry
Molecular Biology
Genetics

Background:

Blood contains diverse biomolecules essential for biological functions.
Recent discoveries reveal stable extracellular RNA (esRNA) of endogenous and exogenous origins in circulation.
The presence of esRNA prompts investigation into its origins, stability, and biological roles.

Purpose of the Study:

To review recent advancements in circulating RNA research.
To discuss the open questions and future directions in the field of extracellular RNA.
To explore the potential origins, functions, and applications of circulating RNA molecules.

Main Methods:

Literature review of recent studies on circulating RNA.
Synthesis of current knowledge on extracellular RNA.
Identification of key unanswered questions in the field.

Main Results:

Extracellular RNA is a stable component of blood, with both internal and external origins.
Significant questions remain regarding RNA export/uptake mechanisms, stability factors, and molecular interactions.
The biological functions and potential applications of circulating RNA are largely unexplored.

Conclusions:

Circulating extracellular RNA represents a significant area for future research.
Understanding the mechanisms and functions of esRNA could lead to novel diagnostic and therapeutic strategies.
Further investigation is crucial to fully elucidate the role of extracellular RNA in biological systems.