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Prevalence of aortic dilation in hypertrophic cardiomyopathy

Renuka Jain1, Adam Helms, Sharlene M Day

  • 1Lillehei Heart Institute and Cardiovascular Division, University of Minnesota Medical School Minneapolis, MN, USA.

American Journal of Cardiovascular Disease
|June 21, 2013
PubMed

Insights

Hypertrophic cardiomyopathy (HCM) is not linked to aortic dilation. This study found no increased frequency of aortic dilation in HCM patients compared to the general population.

Area of Science:

  • Cardiology
  • Cardiovascular Imaging
  • Genetics

Background:

  • Recent research suggests hypertrophic cardiomyopathy (HCM) correlates with aortic stiffness.
  • However, the relationship between HCM and aortic dilation remains unclear.

Purpose of the Study:

  • To investigate the prevalence of aortic dilation in patients with hypertrophic cardiomyopathy.
  • To determine if aortic dilation is associated with HCM characteristics.

Main Methods:

  • Aorta size was measured in 223 HCM patients using echocardiography.
  • Aortic dilation was defined using established criteria accounting for body surface area, age, and gender.
  • HCM characteristics including hypertrophy pattern, maximum wall thickness, and left ventricular outflow tract (LVOT) gradient were assessed.

Main Results:

  • The mean aorta size was 33.0 ± 5.0 mm at the sinuses and 34.0 ± 5.0 mm at the ascending aorta.
  • Aortic dilation was observed in 4.5% of the HCM cohort.
  • Aortic dilation was associated with gender but not with HCM-specific features like LVOT obstruction or hypertrophy extent.

Conclusions:

  • Aortic dilation does not appear to be more frequent in HCM patients than in the general population.
  • The study found no association between aortic dilation and the severity of hypertrophy or LVOT obstruction in HCM.

Keywords:
Aortadilationhypertrophic cardiomyopathy

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