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Updated: May 10, 2026

A Patient-Derived Xenograft Model for Venous Malformation
Published on: June 15, 2020
A keratoacanthoma with venous invasion
Philipp Tschandl1, Cliff Rosendahl, Richard Williamson
1Department of Dermatology, Medical University of Vienna, Austria.
This study reports a rare case of keratoacanthoma exhibiting venous invasion, a characteristic typically associated with malignant tumors. This finding challenges the traditional view of keratoacanthomas as exclusively benign or self-limiting lesions.
Area of Science:
- Dermatology
- Oncology
- Pathology
Background:
- Keratoacanthomas are tumors of the skin.
- Their classification is debated, ranging from a variant of squamous cell carcinoma to a distinct benign lesion.
- Malignant behaviors like perineural invasion are seldom observed.
Purpose of the Study:
- To report a unique case of keratoacanthoma with venous invasion.
- To highlight atypical malignant features in a keratoacanthoma.
Main Methods:
- Histopathological examination of the keratoacanthoma.
- Immunoperoxidase staining.
- Elastic tissue staining.
Main Results:
- The keratoacanthoma demonstrated venous invasion.
- Histological stains confirmed the presence of tumor cells within blood vessels.
Conclusions:
- Keratoacanthomas can exhibit rare malignant features, such as venous invasion.
- This case underscores the importance of thorough histopathological evaluation for accurate diagnosis and patient management.
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