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Updated: May 10, 2026
A 3D Organotypic Melanoma Spheroid Skin Model
Published on: May 18, 2018
Acral melanoma with hyperkeratosis mimicking a pigmented wart
Misaki Ise1, Fumiyo Yasuda, Izumi Konohana
1Division of Dermatology, Hiratsuka City Hospital, Kanagawa, Japan.
Abstract:
Acral lentiginous melanoma (ALM) of the sole sometimes has a hyperkeratotic appearance and mimics a pigmented wart. We report a case of an 81-year-old woman with an ALM on the left sole with hyperkeratosis. Due to its presentation it was difficult to make a correct diagnosis at the beginning. Finally we noticed several small, pigmented macules around the wart-like lesion with the parallel ridge pattern on dermoscopy, strongly suggesting acral melanoma. When a hyperkeratotic pigmented lesion on the sole is encountered, one should rule out melanoma by careful examination of the periphery of the lesion. Dermoscopy is a helpful adjunct for the diagnosis of an unusual case like this.
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