Related Experiment Video

Updated: May 10, 2026

Murine Model of Leukemia Relapse to Induction Chemotherapy for Acute Lymphoblastic Leukemia
08:31

Murine Model of Leukemia Relapse to Induction Chemotherapy for Acute Lymphoblastic Leukemia

Published on: October 17, 2025

[Childhood leukemia]

Olli Lohi1, Jukka Kanerva, Mervi Taskinen

  • 1TAYS, lastenklinikka.

Duodecim; Laaketieteellinen Aikakauskirja
|June 22, 2013
PubMed

Insights

Childhood leukemia, primarily acute lymphoblastic leukemia, now has an 80-90% recovery rate. Research focuses on improving treatments for poor-prognosis cases and reducing therapy for those with good outcomes.

Area of Science:

  • Pediatric Hematology/Oncology
  • Cancer Research
  • Leukemia Pathophysiology

Context:

  • Childhood leukemia represents a significant oncological challenge.
  • Acute lymphoblastic leukemia (ALL) is the most common type in children.
  • Chronic leukemias are rare or not observed in pediatric populations.

Purpose:

  • To summarize the current landscape of childhood leukemia.
  • To highlight the improved prognosis for common leukemia types.
  • To identify future research directions in pediatric leukemia treatment.

Summary:

  • Childhood leukemia predominantly includes acute lymphoblastic leukemia (ALL) and a smaller fraction of acute myelogenous leukemia (AML).
  • Chronic myelogenous leukemia (CML) is rare in children, and chronic lymphocytic leukemia (CLL) is not typically encountered.
  • Prognosis has significantly improved, with recovery rates of 80-90% for lymphocytic leukemia and 60-70% for myelogenous leukemia.

Impact:

  • Improved survival rates for childhood leukemia underscore advances in pediatric oncology.
  • Future research aims to refine treatments for high-risk leukemia groups.
  • Efforts are underway to develop less intensive therapies for leukemia patients with favorable prognoses.

More Related Videos

Pre-clinical Evaluation of Tyrosine Kinase Inhibitors for Treatment of Acute Leukemia10:49

Pre-clinical Evaluation of Tyrosine Kinase Inhibitors for Treatment of Acute Leukemia

Published on: September 18, 2013

Modeling Chemotherapy Resistant Leukemia In Vitro08:41

Modeling Chemotherapy Resistant Leukemia In Vitro

Published on: February 9, 2016

Related Concept Videos

Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
Disorders of Leukocytes01:27

Disorders of Leukocytes

Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune system...
Differentiation of Common Myeloid Progenitor Cells01:15

Differentiation of Common Myeloid Progenitor Cells

Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
Immunodeficiency Diseases01:25

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency disorders...