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Related Concept Videos

Bones of the Upper Limb: Ulna01:15

Bones of the Upper Limb: Ulna

The ulna and radius are parallel bones of the antebrachium or the forearm. The ulna lies medially and consists of a bony tip called the olecranon process at its proximal end. This hook-like projection articulates with the olecranon fossa of the humerus and forms the "hinged" ulnohumeral part of the elbow joint. This joint facilitates forearm extension and flexion while preventing its hyperextension. Similarly, the coronoid process, another bony projection on the proximal/anterior side of the...

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Intratibial Osteosarcoma Cell Injection to Generate Orthotopic Osteosarcoma and Lung Metastasis Mouse Models
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Ulnar osteosarcoma in dogs: 30 cases (1992-2008).

Ramesh K Sivacolundhu1, Jeffrey J Runge, Taryn A Donovan

  • 1Department of Surgery, Animal Medical Center, New York, NY 10065, USA. r_sivacolundhu@yahoo.com

Journal of the American Veterinary Medical Association
|June 22, 2013
PubMed
Summary

In dogs with ulnar osteosarcoma, the telangiectatic subtype significantly worsens survival time. Partial ulnar ostectomy offers a good prognosis without compromising survival, unlike other appendicular sites.

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Area of Science:

  • Veterinary Oncology
  • Comparative Pathology
  • Canine Bone Tumors

Background:

  • Osteosarcoma is a common bone tumor in dogs.
  • Ulnar osteosarcoma presents unique challenges in diagnosis and treatment.
  • Understanding prognostic factors is crucial for effective management.

Purpose of the Study:

  • To investigate the biological behavior of canine ulnar osteosarcoma.
  • To identify predictors of survival time in dogs with this condition.
  • To evaluate treatment outcomes, including surgical interventions and chemotherapy.

Main Methods:

  • A retrospective case series involving 30 dogs with primary ulnar osteosarcoma from nine institutions.
  • Analysis of medical records, including signalment, tumor characteristics, treatment details, and outcomes.
  • Statistical evaluation to identify prognostic factors for survival time.

Main Results:

  • Median disease-free interval was 437 days and median survival time was 463 days.
  • Histologic subtype and lung metastases were negative prognostic factors in univariate analysis.
  • The telangiectatic or telangiectatic-mixed subtype was the sole negative prognostic factor in multivariate analysis (median survival time: 208 days).

Conclusions:

  • Canine ulnar osteosarcoma may have a comparable or better prognosis than osteosarcoma at other appendicular sites.
  • Partial ulnar ostectomy demonstrated a low complication rate and good functional outcomes without compromising survival.
  • The telangiectatic histologic subtype is a significant negative prognostic indicator, warranting further investigation into treatment efficacy.