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Renal response to secretin.

A L Viteri, J W Poppell, J M Lasater

    Journal of Applied Physiology
    |April 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Secretin significantly increases urinary volume, sodium, and bicarbonate excretion in healthy males. This hormone directly impacts renal tubular reabsorption, affecting urine composition after meals.

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    Area of Science:

    • Nephrology
    • Endocrinology
    • Physiology

    Background:

    • Secretin, a hormone released from the duodenum, plays a role in digestion.
    • Its direct effects on renal function are not fully understood.

    Purpose of the Study:

    • To investigate the impact of secretin on renal excretion and urine parameters.
    • To determine if secretin directly influences renal tubular reabsorption.

    Main Methods:

    • Five healthy male volunteers received secretin injections.
    • Urine volume, pH, and electrolyte excretion were measured.
    • Duodenal fluid aspiration was performed in some trials.

    Main Results:

    • Secretin caused a 3-4 fold increase in urinary volume and sodium excretion within 30 minutes.

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  • A significant rise in urinary pH and bicarbonate excretion was observed.
  • Duodenal aspiration enhanced the bicarbonate excretion response.

    • Conclusions:

    • Secretin appears to have a direct effect on renal tubular reabsorption of water and ions.
    • These findings explain transient changes in urine pH following meals.