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Updated: May 10, 2026

Nerve Excitability Assessment in Chemotherapy-induced Neurotoxicity
Published on: April 26, 2012
[Posterior reversible encephalopathy syndrome: 5 chemotherapy related cases]
I San Martín García1, R Urabayen Alberdi1, V Díez Bayona1
1Unidad de Oncohematología Infantil, Servicio de Pediatría, Complejo Hospitalario de Navarra B, Pamplona, España.
Abstract:
Posterior reversible encephalopathy syndrome, previously known as Reversible posterior leukoencephalopathy syndrome, is a clinical-radiological condition characterized by headache, altered mental functioning, seizures and visual alterations, with the magnetic resonance imaging showing cerebral edema, predominantly in the white matter with posterior distribution. Multiple clinical conditions can act as triggers. We present five oncology patients, four of them with acute lymphoblastic leukemia, receiving chemotherapy when they presented with this pathology. A prompt diagnosis, an appropriate therapy for hypertension, and a rapid control of the seizures are the keys to avoiding sequelae.
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