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Updated: May 10, 2026
04:37
Unilateral Ureteral Obstruction Model for Investigating Kidney Interstitial Fibrosis
Published on: April 25, 2025
Prognostic marker for patients with malignant ureter obstruction.
Takeshi Azuma1, Yasushi Nagase, Masaya Oshi
1Department of Urology, Tokyo Metropolitan Tama Medical Center, 2-9-2 Musashi-dai, Fuchu, Tokyo, Japan. azumamifune@yahoo.co.jp
Clinical Genitourinary Cancer
|June 22, 2013
Summary
Prognostic factors for malignant ureteral obstruction include low albumin and sodium levels, high C-reactive protein, and malignant dissemination events. These findings aid in predicting overall survival (OS) for affected patients.
Area of Science:
- Nephrology
- Oncology
- Urology
Background:
- Malignant ureteral obstruction significantly impacts patient prognosis.
- Identifying reliable prognostic factors is crucial for managing patients with this condition.
Purpose of the Study:
- To investigate the relationship between overall survival (OS) and prognostic risk factors in patients with malignant ureteral obstruction.
Main Methods:
- Retrospective evaluation of 214 patients who underwent nephrostomy for malignant ureteral obstruction.
- Univariate and multivariate Cox regression analyses were employed to assess OS predictors.
Main Results:
- The median OS was 6.4 months, with 1-year OS at 26.5%.
- Univariate analysis identified serum creatinine, albumin, sodium, potassium, corrected calcium, C-reactive protein, white blood cell count, and malignant dissemination events as associated with OS.
- Multivariate analysis revealed serum albumin, sodium, C-reactive protein, and malignant dissemination events as independent predictors of OS.
Conclusions:
- Low serum albumin and sodium levels are independent predictors of poor prognosis.
- High serum C-reactive protein levels and the presence of malignant dissemination events before nephrostomy are also associated with a poorer prognosis.
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