Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Sleep-Wake Cycles01:24

Sleep-Wake Cycles

Sleep is an essential physiological process vital to maintaining overall well-being. The reticular activating system (RAS), a network of neurons in the brainstem, regulates wakefulness and sleep. While it may seem passive, sleep consists of distinct cycles, each with its unique characteristics and functions. Two key sleep phases are non-rapid eye movement (NREM) and  rapid eye movement (REM).
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
REM Sleep Behavior Disorder01:15

REM Sleep Behavior Disorder

REM Sleep Behavior Disorder (RBD) is a sleep disorder characterized by the absence of muscle paralysis that normally occurs during the REM phase of sleep. This absence allows individuals to physically act out their dreams, which are often vivid and disturbing. Common behaviors exhibited during episodes include kicking, punching, and yelling. These actions can be dangerous, potentially leading to injuries for the person with RBD or their bed partner.
RBD is significantly associated with...
Sleepwalking and Sleep Talking01:17

Sleepwalking and Sleep Talking

Somnambulism, commonly known as sleepwalking, involves individuals engaging in activities ranging from simple walking to more complex behaviors such as driving. Sleepwalking typically occurs during the slow-wave sleep stages 3 and 4 early in the night when the person is not dreaming, contradicting the myth that sleepwalkers are acting out their dreams.
Factors that increase the likelihood of sleepwalking include sleep deprivation and alcohol consumption. Contrary to common beliefs, it is safe...
Narcolepsy01:07

Narcolepsy

Narcolepsy is a chronic sleep disorder characterized by pervasive, uncontrolled sleepiness and other sleep disturbances. One of its hallmark symptoms is an abrupt transition to REM sleep upon falling asleep, which causes symptoms typically associated with this phase to occur unexpectedly during wakefulness. These include the following symptoms, which typically last from a minute or two to half an hour.
Restless Leg Syndrome and Night Terrors01:27

Restless Leg Syndrome and Night Terrors

Restless Leg Syndrome (RLS), also known as Willis-Ekbom disease, is a neurological disorder characterized by an uncontrollable urge to move the legs due to uncomfortable sensations. These sensations typically occur during periods of rest or inactivity, particularly when lying down or sitting, and can severely disrupt sleep.
The exact cause of RLS is not fully understood, but it is believed to involve dopamine, a neurotransmitter that helps regulate muscle movement. Imbalances in dopamine levels...
Insomnia01:27

Insomnia

Insomnia is a prevalent sleep disorder characterized by difficulty falling asleep, frequent awakenings during the night, and waking up too early without being able to return to sleep. People with insomnia often experience these disruptions at least three nights a week for at least one month. Chronic insomnia, which lasts for at least three months, can lead to increased anxiety, which in turn can worsen sleep difficulties, creating a cycle of sleeplessness and stress.
Multiple factors contribute...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cytology and <i>KRAS/GNAS</i> Molecular Testing of Pancreatic Cyst Fluid for Risk Stratification of Intraductal Papillary Mucinous Neoplasms: A Single-Center Study with Histological Correlation.

Journal of clinical medicine·2026
Same author

Clinical outcomes of rehabilitation with a robotic anthropomorphic exoskeleton in patients with motor-incomplete spinal cord injury: a multicenter randomized controlled trial.

European journal of physical and rehabilitation medicine·2026
Same author

Clinical markers of disease progression in the prodromal to overt alpha-synucleinopathy continuum.

Brain : a journal of neurology·2026
Same author

Genetic associations between post-traumatic stress disorder and REM-sleep behavior disorder.

NPJ Parkinson's disease·2026
Same author

Prognostic impact of pathologically confirmed venous infiltration during upfront pancreatectomy: multicenter survival analysis.

Langenbeck's archives of surgery·2026
Same author

Presynaptic dopaminergic imaging as a neurodegeneration staging biomarker in the alpha-synucleinopathy continuum.

European journal of nuclear medicine and molecular imaging·2026
Same journal

Movement disorders and Parkinson's disease: collaborative and interdisciplinary research to advance understanding of neural circuit dysfunction, pathophysiology, and care: new horizons in technology, neuroimaging, neurophysiology, and genetics toward personalized medicine.

Current opinion in neurology·2026
Same journal

Editorial introduction.

Current opinion in neurology·2026
Same journal

Multimodal mapping of balance dysfunction in Parkinson's disease: a consensus roadmap for research and intervention.

Current opinion in neurology·2026
Same journal

Tourette syndrome: brain neurophysiology, circuit dysfunction, and neuromodulation across invasive and noninvasive approaches.

Current opinion in neurology·2026
Same journal

Dystonia: from phenotypes to genetics and therapeutic advances.

Current opinion in neurology·2026
Same journal

What can we learn from eye movements in movement disorders and Parkinson's disease?

Current opinion in neurology·2026
See all related articles

Related Experiment Video

Updated: May 10, 2026

High-Throughput Small Molecule Drug Screening For Age-Related Sleep Disorders Using Drosophila melanogaster
05:59

High-Throughput Small Molecule Drug Screening For Age-Related Sleep Disorders Using Drosophila melanogaster

Published on: October 20, 2023

Sleep and movement disorders.

Maria P Giannoccaro1, Elena Antelmi, Giuseppe Plazzi

  • 1IRCCS Istituto delle Scienze Neurologiche, University of Bologna, Bologna, Italy.

Current Opinion in Neurology
|June 22, 2013
PubMed
Summary
This summary is machine-generated.

Sleep disturbances, particularly rapid eye movement sleep behavior disorder (RBD), are early markers for neurodegeneration and dementia in movement disorders like Parkinson's disease. New research clarifies links between sleep and movement disorders, aiding diagnosis and understanding pathophysiology.

More Related Videos

A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice
06:23

A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice

Published on: September 22, 2020

Chronic Sleep Deprivation in Mouse Pups by Means of Gentle Handling
03:46

Chronic Sleep Deprivation in Mouse Pups by Means of Gentle Handling

Published on: October 11, 2018

Related Experiment Videos

Last Updated: May 10, 2026

High-Throughput Small Molecule Drug Screening For Age-Related Sleep Disorders Using Drosophila melanogaster
05:59

High-Throughput Small Molecule Drug Screening For Age-Related Sleep Disorders Using Drosophila melanogaster

Published on: October 20, 2023

A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice
06:23

A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice

Published on: September 22, 2020

Chronic Sleep Deprivation in Mouse Pups by Means of Gentle Handling
03:46

Chronic Sleep Deprivation in Mouse Pups by Means of Gentle Handling

Published on: October 11, 2018

Area of Science:

  • Neurology
  • Sleep Medicine
  • Neuroscience

Background:

  • Sleep disturbances are common in movement disorders, notably Parkinson's disease.
  • Rapid eye movement sleep behavior disorder (RBD) is a significant early indicator of neurodegeneration.
  • RBD may also predict future dementia and a poorer overall prognosis.

Purpose of the Study:

  • To review sleep disturbances across various movement disorders.
  • To explore the convergence of movement disorders and dissociative states.
  • To highlight recent advancements in understanding the sleep-movement disorder relationship.

Main Methods:

  • Literature review of recent studies on sleep disturbances in movement disorders.
  • Analysis of pathogenetic mechanisms linking sleep disorders and neurodegeneration.
  • Examination of the role of neurotransmitter systems and genetic factors in sleep regulation.

Main Results:

  • RBD is a key focus for understanding neurodegenerative pathways and developing therapies.
  • Excessive daytime sleepiness in Parkinson's disease is linked to monoaminergic system disruption.
  • Dopamine's role in circadian rhythm regulation and clock gene expression is under investigation.
  • A strong connection between primary sleep disorders and movement disorders is increasingly recognized.

Conclusions:

  • Recent research offers novel insights into the relationship between sleep and movement disorders.
  • These findings can potentially streamline diagnostic procedures.
  • New understanding sheds light on the underlying pathophysiological mechanisms.