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Immunogenic tumor cell death induced by chemoradiotherapy: molecular mechanisms and a clinical translation
K Kono1, K Mimura, R Kiessling
1Department of Surgery, National University of Singapore, Singapore. surkoji@nus.edu.sg
Abstract:
Chemoradiotherapy can induce immunogenic cell death, triggering danger signals such as high-mobility group box 1 protein, and resulting in T-cell immunity. This concept can potentially be harnessed for clinical therapy to enhance tumor-specific immunity. There is however limited information to translate this theory directly in a clinical setting. In this review, we will discuss and summarize molecular and cellular mechanisms underlying immunogenic tumor cell death induced by chemoradiotherapy, with emphasis on a clinical translation.
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