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Published on: November 11, 2022
Enhancement of polydatin on inward rectifier potassium channel current in rat ventricular myocytes
Yan Wei1, Jing-Jing Zhou, Jing Yang
1Department of Physiology, Hebei Medical University, Shijiazhuang 050017, China; Department of Electrophysiology, Institute of Cardiovascular Research, Luzhou Medical College, Luzhou 646000, China; Hebei Key Laboratory of Medical Biotechnology, Shijiazhuang 050017, China.
Abstract:
The aim of this study was to investigate the effect of polydatin on transient outward potassium channel current (Ito), steady-state outward potassium channel current (Iss) and inward rectifier potassium channel current (IK1) in ventricular myocytes of rat using the whole-cell patch clamp technique. The results showed: (1) Polydatin (above 10 µmol/L) increased IK1 of ventricular myocytes in a non-concentration dependent manner. (2) Polydatin neither had any effect on Ito peak current of ventricular myocytes, nor changed activation, inactivation and recovery kinetics of Ito. (3) Polydatin had no effect on Iss of ventricular myocytes. These results suggest that polydatin enhances IK1 channel activity, but has no effect on Ito and Iss channels in rat ventricular myocytes, which might be one of the ionic mechanisms for antiarrhythmic effect of polydatin.
