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Updated: May 10, 2026

Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography
Published on: December 2, 2022
Dermal and conjunctival melanocytic proliferations in diffuse uveal melanocytic proliferation
J S Pulido1, T J Flotte, H Raja
1Department of Ophthalmology, Mayo Clinic, Rochester, MN, USA.
Aim:
The goal of this case report is to describe the dermatologic and conjunctival findings in a case of bilateral diffuse uveal melanocytic proliferation (BDUMP), a paraneoplastic syndrome usually associated with gynecologic cancers. There is little information about other dermatologic melanocytic findings in these patients.
Methods:
Histologic and fluorescent in situ hybridization (FISH) analysis of three separate skin biopsies, one of which was separated by 21 months from the others, were performed in a 71-year-old patient with BDUMP to assess for histologic and chromosomal abnormality. Conjunctival histologic evaluation was also done.
Results:
Dermal melanocytic proliferation was seen in each specimen. The cells were spindle type with mitotic activity. FISH analysis showed a normal copy of chromosomes. The conjunctival sample also showed normal FISH analysis.
Conclusion:
BDUMP is associated with multifocal dermal and conjunctival melanocytic proliferation.
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