Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 10, 2026

Optrode Array for Simultaneous Optogenetic Modulation and Electrical Neural Recording
06:36

Optrode Array for Simultaneous Optogenetic Modulation and Electrical Neural Recording

Published on: September 1, 2022

On-chip optical stimulation and electrical recording from cells.

Alexey Yakushenko1, Zheng Gong, Vanessa Maybeck

  • 1Institute of Bioelectronics (PGI-8/ICS-8) and JARA-Fundamentals of Future Information Technology, Forschungszentrum Jülich, 52425 Jülich, Germany.

Journal of Biomedical Optics
|June 22, 2013
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Beyond Capacitance Ratio: Electrolyte Voltage Division and a New Impedance Model for Organic Electrochemical Transistors.

ACS applied materials & interfaces·2026
Same author

Enhanced magnetic moment discrimination for multiplex nanoparticle quantification via dual-frequency nonlinearity probing.

Communications engineering·2026
Same author

Transfer-printed yellow and red InGaN micro-LEDs on diamond for ultra-low-power high-speed optical interconnects.

Nature communications·2026
Same author

A label-free electrochemical aptasensor enables ultrasensitive and specific detection of neurofilament light.

Biosensors & bioelectronics·2026
Same author

Self-folding graphene scaffolds with integrated electronics for cardiac tissue engineering.

Nanoscale·2026
Same author

Dual-Channel Interdigitated Aptamer-Based Sensors for Rapid Small-Molecule Detection in Biofluids.

Angewandte Chemie (International ed. in English)·2026

This study introduces a novel optoelectrical device for in vitro optical stimulation and electrophysiological recording. The system enables simultaneous light control and electrical monitoring of optogenetically modified cells directly on-chip.

Area of Science:

  • Biomedical Engineering
  • Neuroscience
  • Optoelectronics

Background:

  • Optogenetics enables precise control of genetically modified cells using light.
  • Simultaneous optical stimulation and electrophysiological recording are crucial for studying cellular networks.
  • Existing methods often require complex external equipment and multiple components.

Purpose of the Study:

  • To develop an integrated optoelectrical device for simultaneous in vitro optical stimulation and electrophysiological recording.
  • To demonstrate the device's capability for culturing and monitoring cells directly on-chip.
  • To showcase the potential for studying optogenetically modified cells in a simplified experimental setup.

Main Methods:

  • Fabrication of a device integrating micropixelated InGaN LEDs with a planar microelectrode array.

More Related Videos

Optical Control of Living Cells Electrical Activity by Conjugated Polymers
10:16

Optical Control of Living Cells Electrical Activity by Conjugated Polymers

Published on: January 28, 2016

Silicon Nanowires and Optical Stimulation for Investigations of Intra- and Intercellular Electrical Coupling
08:58

Silicon Nanowires and Optical Stimulation for Investigations of Intra- and Intercellular Electrical Coupling

Published on: January 28, 2021

Related Experiment Videos

Last Updated: May 10, 2026

Optrode Array for Simultaneous Optogenetic Modulation and Electrical Neural Recording
06:36

Optrode Array for Simultaneous Optogenetic Modulation and Electrical Neural Recording

Published on: September 1, 2022

Optical Control of Living Cells Electrical Activity by Conjugated Polymers
10:16

Optical Control of Living Cells Electrical Activity by Conjugated Polymers

Published on: January 28, 2016

Silicon Nanowires and Optical Stimulation for Investigations of Intra- and Intercellular Electrical Coupling
08:58

Silicon Nanowires and Optical Stimulation for Investigations of Intra- and Intercellular Electrical Coupling

Published on: January 28, 2021

  • Culturing of HL-1 cells (cardiomyocyte-like cell line) directly on the chip.
  • Transfection of HL-1 cells with channelrhodopsin for light sensitivity.
  • Monitoring of action potentials using extracellular electrical recordings.
  • On-chip optical stimulation to trigger network activity and visualization via calcium imaging.

    • Main Results:

    • Successful integration of optical stimulation and electrophysiological recording capabilities in a single device.
    • Demonstrated ability to culture and record from HL-1 cells on the chip.
    • Achieved optical triggering of network activity in confluent HL-1 cell cultures.
    • Verified functionality for electrophysiological experiments with optogenetically modified cells.

    Conclusions:

    • The developed optoelectrical device offers a streamlined platform for in vitro optogenetics.
    • It eliminates the need for external optical components, simplifying experimental procedures.
    • The system holds significant potential for advancing research in cellular electrophysiology and neuroscience.