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Related Concept Videos

The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
Mitochondria01:37

Mitochondria

Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...

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Related Experiment Video

Updated: May 10, 2026

Multimodal Study of Murine Cardiovascular Remodeling: Four-Dimensional Ultrasound and Mass Spectrometry Imaging
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Published on: January 10, 2025

Can proteomics yield insight into aging aorta?

Zongming Fu1, Mingyi Wang, Allen Everett

  • 1Department of Pediatrics, The Johns Hopkins University, Baltimore, MD 21224, USA.

Proteomics. Clinical Applications
|June 22, 2013
PubMed
Summary
This summary is machine-generated.

Proteomic analysis of the aging aorta reveals key proteins like milk fat globule-EGF factor 8, matrix metalloproteinase type-2, and vitronectin. These proteins may serve as biomarkers for vascular health and potential therapeutic targets for age-related vascular diseases.

Keywords:
Aging aortaBiomarkerMilk fat globule-EGF factor 8Therapeutic target

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Last Updated: May 10, 2026

Multimodal Study of Murine Cardiovascular Remodeling: Four-Dimensional Ultrasound and Mass Spectrometry Imaging
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Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice
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Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice

Published on: February 20, 2019

Area of Science:

  • Gerontology
  • Vascular Biology
  • Proteomics

Background:

  • Aging aorta undergoes significant structural and physiological changes.
  • Proteomic analysis offers insights into the molecular mechanisms of aortic aging.
  • Understanding these changes is crucial for predicting vascular health.

Purpose of the Study:

  • To investigate insights from proteomic studies on the intact aging aorta and vascular smooth muscle cells.
  • To identify proteins associated with the natural history of aortic aging.

Main Methods:

  • Application of advanced proteomic technologies to analyze protein quantities in the aging aorta.
  • Focus on studies involving intact aging aorta or vascular smooth muscle cells.

Main Results:

  • Identification of several proteins closely associated with aging in the rat aorta.
  • Key proteins identified include milk fat globule-EGF factor 8, matrix metalloproteinase type-2, and vitronectin.

Conclusions:

  • These identified proteins could serve as indicators of vascular health.
  • The identified proteins may be explored as potential therapeutic targets for aging-related vascular diseases.