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Multi-chromatic pH-activatable 19F-MRI nanoprobes with binary ON/OFF pH transitions and chemical-shift barcodes

Xiaonan Huang1, Gang Huang, Shanrong Zhang

  • 1Department of Pharmacology, Harold C. Simmons Comprehensive Cancer Center, UT Southwestern Medical Center at Dallas, 5323 Harry Hines Blvds, Dallas, TX 75390, USA.

Angewandte Chemie (International Ed. in English)
|June 22, 2013
PubMed
Abstract

No abstract available in PubMed .

Keywords:
19F MRIimaging agentsmicellespH imagingpolymers

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Labeling DNA Probes

DNA probes are fragments of DNA labeled with a reporter tag to enable their detection or purification. The resulting labeled DNA probes can then hybridize to target nucleic acid sequences through complementary base-pairing, and may be used to recover or identify these regions.
Radioisotopes, fluorophores, or small molecule binding partners like biotin or digoxigenin, are the most widely used reporter tags for labeling DNA probes. These labels can be attached to the probe DNA molecule via...

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