Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hypoxic viscosity and diabetic retinopathy.

T Rimmer1, J Fleming, E M Kohner

  • 1Department of Medicine, Royal Postgraduate Medical School, London.

The British Journal of Ophthalmology
|July 1, 1990
PubMed
Summary

Diabetic blood viscosity increases when deoxygenated, particularly in patients with retinopathy. This finding suggests a potential mechanism for diabetic retinopathy progression due to altered blood flow dynamics.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Notes on the Wounded of the Royal Spanish Army, Made during a Short Visit to the North of Spain.

British medical journal·2010
Same author

A higher-order-mode erbium-doped-fiber amplifier.

Optics express·2010
Same author

Review of a series of confusional states seen in consultation on general hospital services.

Journal of the American Medical Women's Association·2010
Same author

Observations on the defenses against a transference neurosis.

Psychiatry·2010
Same author

The modern treatment of pernicious anaemia.

The Medical press·2010
Same author

Sand-fly fever; review of 664 cases.

Lancet (London, England)·2010

Area of Science:

  • Ophthalmology
  • Hematology
  • Diabetology

Background:

  • Diabetic retinopathy shares features with sickle retinopathy, including vascular changes.
  • Low oxygen levels in the retina can cause sickling of red blood cells.
  • Abnormal hemoglobin in poorly controlled diabetes may affect blood viscosity.

Purpose of the Study:

  • To investigate if diabetic blood becomes more viscous when deoxygenated, similar to sickle cell disease.
  • To compare blood viscosity changes in normal individuals, diabetics without retinopathy, and diabetics with retinopathy.

Main Methods:

  • Whole blood viscosity was measured under oxygenated and deoxygenated conditions.
  • Participants included 23 normal individuals, 23 diabetics without retinopathy, and 34 diabetics with retinopathy.
  • Viscosity was measured at a shear rate of 230 s-1, relevant to retinal veins.

Main Results:

  • Blood viscosity did not change significantly with deoxygenation in normal individuals or diabetics without retinopathy.
  • Blood viscosity significantly increased upon deoxygenation in diabetic patients with retinopathy (p=0.027).
  • The hypoxic viscosity ratio correlated with total serum cholesterol (r=0.44, p=0.018).

Conclusions:

  • Deoxygenation increases blood viscosity in diabetic retinopathy patients.
  • This increased viscosity may contribute to the progression of diabetic retinopathy by altering retinal hemodynamics.
  • Serum cholesterol levels are associated with increased blood viscosity under hypoxic conditions in diabetes.

Related Experiment Videos