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Related Experiment Video

Updated: May 10, 2026

Optical Clearing and Labeling for Light-sheet Fluorescence Microscopy in Large-scale Human Brain Imaging

Optical Clearing and Labeling for Light-sheet Fluorescence Microscopy in Large-scale Human Brain Imaging

Published on: January 26, 2024

BigBrain: an ultrahigh-resolution 3D human brain model.

Katrin Amunts¹, Claude Lepage, Louis Borgeat

¹Institute of Neuroscience and Medicine (INM-1, INM-4), Research Centre Jülich, Jülich, Germany. k.amunts@fz-juelich.de

Science (New York, N.Y.)

|June 22, 2013

Summary

This summary is machine-generated.

A new ultrahigh-resolution 3D human brain model, BigBrain, offers unprecedented microscopic detail for neuroanatomy. This free tool enables advanced brain mapping and simulations, redefining traditional anatomical studies.

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Last Updated: May 10, 2026

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Published on: January 26, 2024

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3D Scanning Technology Bridging Microcircuits and Macroscale Brain Images in 3D Novel Embedding Overlapping Protocol

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Published on: May 12, 2019

Area of Science:

Neuroscience
Neuroanatomy
Brain Mapping

Background:

Reference brains are crucial for integrating multimodal data in human brain mapping.
Existing reference brains lack microscopic detail, limiting functional insights.

Purpose of the Study:

To create an ultrahigh-resolution 3D human brain model with cellular-level detail.
To provide a publicly available tool for advanced neuroanatomical research and simulation.

Main Methods:

Reconstruction of 7404 histological sections.
Development of a 3D model at 20-micrometer resolution.

Main Results:

Creation of the BigBrain, an ultrahigh-resolution 3D human brain model.
BigBrain provides detailed microscopic neuroanatomical information.

Conclusions:

BigBrain redefines traditional neuroanatomy maps by offering microscopic insights.
The model facilitates testing hypotheses on neural connectivity and genetic patterning.