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Dietary derived compounds in cancer chemoprevention

Ewa Langner1, Wojciech Rzeski

  • 1Department of Medical Biology, Institute of Agricultural Medicine, Lublin, Poland.

Contemporary Oncology (Poznan, Poland)
|June 22, 2013
PubMed

Insights

Dietary compounds show promise for cancer chemoprevention with low toxicity. This review highlights key agents like green tea polyphenols, fatty acids, and vitamins, and their molecular targets.

Area of Science:

  • Oncology
  • Nutritional Science
  • Pharmacology

Background:

  • Cancer chemoprevention utilizes natural or synthetic agents to inhibit or reverse cancer progression.
  • Diet-derived compounds are increasingly studied for their therapeutic potential and lower toxicity compared to conventional drugs.

Purpose of the Study:

  • To review recent findings on promising dietary chemopreventive agents.
  • To discuss the molecular targets and pathways influenced by these natural compounds.

Main Methods:

  • Literature review of recent scientific findings.
  • Survey of established and emerging dietary chemopreventive agents.
  • Discussion of molecular mechanisms of action.

Main Results:

  • Identified key dietary chemopreventive agents including green tea polyphenols (catechins), polyunsaturated fatty acids, carotenoids, glucosinolates/isothiocyanates, vitamin D, folate, calcium, and selenium.
  • Highlighted the generally low toxicity profile of these compounds.
  • Briefly discussed the molecular targets and intrinsic pathways affected by these natural agents.

Conclusions:

  • Dietary compounds represent a significant area of research in cancer chemoprevention.
  • These natural agents offer a promising, low-toxicity approach to suppressing or reversing cancer development.
  • Further investigation into their molecular targets can optimize their therapeutic application.
Keywords:
cancer chemopreventioncarotenoidsglucosinolatesgreen tea polyphenolspolyunsaturated fatty acids

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