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Effect of combination of rapamycin and cisplatin on human cervical carcinoma Hela cells
Lu Han1, Jie-Ling Wu, Li-Xiao Yang
1Dalian Obstetrics and Gynecology Hospital, Dalian, Liaoning, China.
Aim Of The Study:
To evaluate the effect of combined use of rapamycin and cisplatin against Hela cells in vitro.
Material And Methods:
The inhibitory effects of rapamycin and cisplatin, used alone or combination, on the proliferation of Hela cell were measured with MTT assay and median-effect plot analysis.
Results:
Combined use of rapamycin and cisplatin significantly improved the chemotherapeutic effect against Hela cells. The inhibitory rates were dose-dependent. Rapamycin and cisplatin showed synergistic effects in the chemotherapy of Hela cells (q > 1.15, King's formula).
Conclusions:
Combined use of rapamycin and cisplatin significantly improves the chemotherapeutic effect against Hela cells.
