[Protective lysosomal autoregulatory mechanism and its disorders in diphtheric intoxication]

Diphterial intoxication was established in rabbits by means of bolus 1 DLM/kg intravenous injection of diphterial toxin. Different types of N-acetyl-beta-1)-galactosaminidase's activity were determined in lysosomal fraction which had been obtained after ultracentrifugation of the left and right ventricles' tissue of the heart. It has been found that the mechanism of fixation's reinforcement of this enzyme exists in lysosomes in case of increasing of its activity. This mechanism was damaged on the different stages of diphterial intoxication that influenced negatively the heart's contractility.