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Updated: May 10, 2026

A Label-free Technique for the Spatio-temporal Imaging of Single Cell Secretions
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A Label-free Technique for the Spatio-temporal Imaging of Single Cell Secretions

Published on: November 23, 2015

Multiplexed plasmon sensor for rapid label-free analyte detection.

Christina Rosman1, Janak Prasad, Andreas Neiser

  • 1Institute of Physical Chemistry, University of Mainz , Duesbergweg 10-14, D-55128 Mainz, Germany.

Nano Letters
|June 25, 2013
PubMed
Summary
This summary is machine-generated.

We developed a novel multiplexed sensor using gold nanorods for efficient protein detection. This technology offers nanomolar sensitivity and potential for large-scale multiplexing in diagnostics and environmental monitoring.

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Analytical Chemistry

Background:

  • Multiplexed detection of proteins is crucial for disease diagnostics and environmental monitoring.
  • Current methods often require large sample volumes and lack cost-effectiveness.
  • There is a need for sensitive, scalable, and reusable protein detection platforms.

Purpose of the Study:

  • To develop an efficient and cost-effective multiplexed sensor for protein detection.
  • To utilize aptamer-functionalized gold nanorods for specific protein recognition.
  • To demonstrate the sensor's sensitivity, reusability, and scalability.

Main Methods:

  • Fabrication of a sensor platform with randomly deposited aptamer-functionalized gold nanorods.
  • Utilizing dark-field spectroscopy to monitor the spectral position of plasmon resonances of individual nanorods.
  • Testing the sensor's specificity and sensitivity towards different proteins.

Main Results:

  • Demonstrated specific protein detection using aptamer-functionalized gold nanorods.
  • Achieved nanomolar sensitivity for protein detection.
  • Showcased sensor recyclability and the potential for upscaling to detect hundreds or thousands of targets.

Conclusions:

  • The novel multiplexed sensor offers a promising solution for sensitive and scalable protein detection.
  • Aptamer-functionalized gold nanorods provide a versatile platform for various diagnostic and monitoring applications.
  • This technology has the potential to significantly advance disease detection and water quality monitoring.