Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

"A combination of everything": a mixed-methods approach to the factors which autistic people consider important in suicidality.

Autism in adulthood : challenges and management·2025
Same author

A complex systems approach to obesity: a transdisciplinary framework for action.

Perspectives in public health·2023
Same author

UK-wide risk factor study of broiler carcases highly contaminated with Campylobacter.

Zoonoses and public health·2023
Same author

Sensory processing profiles and autistic symptoms as predictive factors in autism spectrum disorder and Williams syndrome.

Journal of intellectual disability research : JIDR·2020
Same author

Is Camouflaging Autistic Traits Associated with Suicidal Thoughts and Behaviours? Expanding the Interpersonal Psychological Theory of Suicide in an Undergraduate Student Sample.

Journal of autism and developmental disorders·2019
Same author

Measuring vision using innate behaviours in mice with intact and impaired retina function.

Scientific reports·2019
Same journal

Characteristics of Splenic CD8αβ<sup>+</sup> γδT Cells in Plasmodium yoelii Infection.

Parasite immunology·2026
Same journal

T-Bet Modulates Plasmodium-Specific CD4<sup>+</sup> T Cell Differentiation and Anti-Malarial Immunity During Blood-Stage Infection.

Parasite immunology·2026
Same journal

Leishmania (Leishmania) Infantum Living in Nature Secretes a Higher Concentration of Extracellular Vesicles, Suggesting Greater Infectious Potential.

Parasite immunology·2026
Same journal

IL-25 Enhances Eosinophil-Associated Inflammation in Angiostrongylus cantonensis-Infected Mice.

Parasite immunology·2026
Same journal

Potential of Postbiotics as Antiparasitic Agents.

Parasite immunology·2026
Same journal

No Evidence for Association Between ICOS (a T-Cell Co-Stimulatory Molecule) Gene Polymorphisms and Anti-MSP-1<sub>19</sub> IgG Response in Venezuelan Endemic Plasmodium vivax Malaria.

Parasite immunology·2026
See all related articles

Related Experiment Video

Updated: May 10, 2026

Bioluminescence Imaging to Detect Late Stage Infection of African Trypanosomiasis
07:59

Bioluminescence Imaging to Detect Late Stage Infection of African Trypanosomiasis

Published on: May 18, 2016

Imaging African trypanosomes.

L MacLean1, E Myburgh, J Rodgers

  • 1Centre for Immunology and Infection, Department of Biology/Hull York Medical School, University of York, Heslington, York, UK. l.m.maclean@dundee.ac.uk

Parasite Immunology
|June 25, 2013
PubMed
Summary
This summary is machine-generated.

Imaging tools offer new insights into Trypanosoma brucei, the parasite causing human African trypanosomiasis (HAT). This review explores how advanced imaging aids in understanding HAT progression and developing novel drug candidates for late-stage treatment.

Keywords:
RNA interferenceTrypanosoma sppanimal modelelectron microscopyin vivo imagingtools and techniques

More Related Videos

Quantitative 3D Imaging of Trypanosoma cruzi-Infected Cells, Dormant Amastigotes, and T Cells in Intact Clarified Organs
08:17

Quantitative 3D Imaging of Trypanosoma cruzi-Infected Cells, Dormant Amastigotes, and T Cells in Intact Clarified Organs

Published on: June 23, 2022

Superior Auto-Identification of Trypanosome Parasites by Using a Hybrid Deep-Learning Model
08:20

Superior Auto-Identification of Trypanosome Parasites by Using a Hybrid Deep-Learning Model

Published on: October 27, 2023

Related Experiment Videos

Last Updated: May 10, 2026

Bioluminescence Imaging to Detect Late Stage Infection of African Trypanosomiasis
07:59

Bioluminescence Imaging to Detect Late Stage Infection of African Trypanosomiasis

Published on: May 18, 2016

Quantitative 3D Imaging of Trypanosoma cruzi-Infected Cells, Dormant Amastigotes, and T Cells in Intact Clarified Organs
08:17

Quantitative 3D Imaging of Trypanosoma cruzi-Infected Cells, Dormant Amastigotes, and T Cells in Intact Clarified Organs

Published on: June 23, 2022

Superior Auto-Identification of Trypanosome Parasites by Using a Hybrid Deep-Learning Model
08:20

Superior Auto-Identification of Trypanosome Parasites by Using a Hybrid Deep-Learning Model

Published on: October 27, 2023

Area of Science:

  • Parasitology
  • Neuroscience
  • Medical Imaging

Background:

  • Trypanosoma brucei causes human African trypanosomiasis (HAT), a fatal disease.
  • Late-stage HAT involves parasite invasion of the central nervous system (CNS).
  • Current treatments for late-stage HAT are toxic or difficult to administer.

Purpose of the Study:

  • To review the application of imaging tools in understanding T. brucei biology and HAT.
  • To explore how imaging aids in studying parasite-host interactions and CNS invasion.
  • To assess the utility of imaging in screening for new HAT drug candidates.

Main Methods:

  • Fluorescent confocal microscopy of live T. brucei cells in culture.
  • Whole-animal imaging techniques for in vivo studies.
  • Review of current literature on imaging applications in HAT research.

Main Results:

  • Imaging provides insights into T. brucei biology and host-parasite interactions.
  • Advanced imaging helps visualize trypanosome invasion of the central nervous system.
  • Imaging tools are valuable for assessing disease progression and drug efficacy.

Conclusions:

  • Imaging technologies are crucial for advancing our understanding of HAT.
  • These tools can accelerate the discovery and development of new late-stage HAT therapies.
  • Further application of imaging holds promise for combating this neglected tropical disease.