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AGT M235T polymorphisms and ischemic stroke risk: a meta-analysis

Baoyun Liang1, Lilan Qin, Huijun Wei

  • 1Department of Internal Neurology, First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning, Guangxi, China.

Journal of the Neurological Sciences
|June 25, 2013
PubMed

Insights

This meta-analysis found the AGT M235T polymorphism is a risk factor for ischemic stroke (IS) in Asians. However, this association was not observed in Caucasians, suggesting ethnic differences in IS genetic risk factors.

Area of Science:

  • Genetics
  • Epidemiology
  • Cardiovascular Disease

Background:

  • The angiotensinogen (AGT) M235T polymorphism has been investigated for its association with ischemic stroke (IS).
  • Previous studies yielded inconsistent results regarding this association.
  • A comprehensive meta-analysis is needed to clarify the relationship between AGT M235T polymorphism and IS risk.

Purpose of the Study:

  • To conduct a meta-analysis evaluating the association between the AGT M235T polymorphism and ischemic stroke (IS).
  • To assess potential ethnic differences in the association between AGT M235T polymorphism and IS.
  • To explore the overall risk conferred by the AGT M235T polymorphism across different genetic models.

Main Methods:

  • Systematic literature search of multiple databases (PubMed, EMBASE, CNKI, CBM, Wanfang, Chongqing VIP) up to January 2013.
  • Meta-analysis using STATA software, calculating Odds Ratios (OR) with 95% Confidence Intervals (CI).
  • Assessment of heterogeneity (Q-test, I² statistic) and publication bias (funnel plots, Egger's regression test). Cumulative meta-analysis was performed.

Main Results:

  • A significant association between AGT M235T polymorphism and IS was found across multiple genetic models (dominant, recessive, over-dominant, co-dominant, allele).
  • Subgroup analyses revealed significant associations in Asian populations and with hospital-based controls.
  • Cumulative analysis indicated a tendency towards a significant association over time, but an opposite trend was observed in Caucasians.

Conclusions:

  • The AGT M235T polymorphism may serve as a risk factor for ischemic stroke (IS) in Asian populations.
  • The association between AGT M235T polymorphism and IS appears to be ethnicity-dependent, with no significant link found in Caucasians.
  • Further research is warranted to validate these findings and elucidate the ethnic-specific role of AGT M235T polymorphism in IS pathogenesis.
Keywords:
AGT geneIschemic strokeM235TMeta-analysisPolymorphismRenin-angiotensin-aldosterone system

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