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Elective bladder-sparing treatment for muscle invasive bladder cancer
G Lendínez-Cano1, J Rico-López1, S Moreno1
1Servicio de Urología, Hospital Universitario Nuestra Señora de Valme, Sevilla, España.
Actas Urologicas Espanolas
|June 25, 2013
Summary
Bladder-sparing treatment for muscle invasive bladder cancer (MIBC) in selected patients shows promising long-term results, offering an alternative to radical cystectomy. This approach achieved good survival rates and preserved bladders in a majority of cases.
Area of Science:
- Urology
- Oncology
Background:
- Radical cystectomy is the standard treatment for localized muscle-invasive bladder cancer (MIBC).
- Bladder-sparing approaches are being explored as alternatives for select patients.
Purpose of the Study:
- To evaluate the long-term outcomes of bladder-sparing treatment for localized MIBC in carefully selected patients.
- To compare bladder-sparing treatment efficacy against radical cystectomy standards.
Main Methods:
- Retrospective analysis of 30 MIBC patients (T2 stage, solitary lesion <5cm, disease-free after TURB) treated between 1991-2010.
- Treatment modalities included transurethral resection of bladder tumor (TURB) alone, or with chemotherapy and/or radiotherapy.
- Strict selection criteria and follow-up protocols were applied.
Main Results:
- Mean follow-up was 88.7 months.
- 46.6% of patients remained disease-free, with 33% experiencing recurrence as non-muscle invasive bladder cancer.
- 5-year bladder preservation rate was 71%, with an overall survival of 79% and cancer-specific survival of 85%.
Conclusions:
- Bladder-sparing treatment, including TURB with or without chemotherapy/radiotherapy, is a viable alternative to radical cystectomy for carefully selected MIBC patients.
- This approach demonstrates good long-term oncological control and functional outcomes.
