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Related Concept Videos

Regulation of Food Intake01:30

Regulation of Food Intake

Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...
Neural Circuits01:25

Neural Circuits

Neural circuits and neuronal pools are two of the main structures found in the nervous system. Neural circuits are networks of neurons that work together to carry out a specific task or process. They consist of interconnected neurons and glial cells, which provide structural and metabolic support.
Neuronal pools are collections of nerve cells with similar functions and interact through chemical and electrical signals. These pools include both interneurons (the central neural circuit nodes that...
Neural Regulation01:37

Neural Regulation

Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
Diencephalon: Hypothalamus and Coordination01:23

Diencephalon: Hypothalamus and Coordination

The hypothalamus is a small yet highly complex and essential brain region that plays a crucial role in regulating various bodily functions. Anatomically, it is located at the base of the brain, just above the brainstem and below the thalamus, forming part of the limbic system.
The hypothalamus interacts with other brain regions, including the pituitary gland, through a direct physical connection called the hypothalamic-pituitary axis. The hypothalamus receives somatic and visceral inputs and...
Enteric Nervous System: Regulation of GI Motor Activity01:11

Enteric Nervous System: Regulation of GI Motor Activity

The Enteric Nervous System (ENS) plays a pivotal role in regulating gastrointestinal or GI motor activity. This complex network of nerves, deeply embedded within the gut wall, responds to changes in the gut environment and receives input from both the autonomic nervous system and the central nervous system. By doing so, the ENS operates various programs tailored to the body's nutritional status and needs.
During periods of fasting, the ENS initiates the migrating myoelectric complex, a program...
Diencephalon: Anatomical Regions01:30

Diencephalon: Anatomical Regions

The diencephalon, etymologically translated as 'through brain,' plays an integral role as the conduit between the cerebrum and the vast extent of the nervous system. However, the olfactory system is an exception, as it interfaces directly with the cerebrum. The diencephalon, deeply ensconced beneath the cerebrum, primarily consists of three paired structures — the thalamus, hypothalamus, and epithelamus. It also includes accessory structures such as the subthalamus, which houses the subthalamic...

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Related Experiment Video

Updated: May 10, 2026

Simultaneous Detection of c-Fos Activation from Mesolimbic and Mesocortical Dopamine Reward Sites Following Naive Sugar and Fat Ingestion in Rats
08:07

Simultaneous Detection of c-Fos Activation from Mesolimbic and Mesocortical Dopamine Reward Sites Following Naive Sugar and Fat Ingestion in Rats

Published on: August 24, 2016

Neuronal circuits that regulate feeding behavior and metabolism.

Jong-Woo Sohn1, Joel K Elmquist, Kevin W Williams

  • 1Division of Hypothalamic Research, Department of Internal Medicine, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA.

Trends in Neurosciences
|June 25, 2013
PubMed
Summary

Central nervous system neurons control eating and metabolism using signals. Recent genetic and neuroscience tools reveal key cellular and circuit mechanisms regulating feeding, energy, and glucose balance.

Keywords:
GABAagouti-related peptideelectrophysiologyglutamatemelanocortin receptorneuropeptide Y receptor

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Last Updated: May 10, 2026

Simultaneous Detection of c-Fos Activation from Mesolimbic and Mesocortical Dopamine Reward Sites Following Naive Sugar and Fat Ingestion in Rats
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Published on: August 24, 2016

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Area of Science:

  • Neuroscience
  • Metabolism
  • Neuroendocrinology

Background:

  • Central nervous system (CNS) neurons integrate humoral and neural signals to regulate ingestive behavior and metabolism.
  • Understanding these central mechanisms is crucial for addressing metabolic disorders.

Purpose of the Study:

  • To review recent advances in understanding the cellular mechanisms and neural circuits controlling feeding behavior, energy expenditure, and glucose homeostasis.
  • To integrate findings from mouse genetics, neuroanatomy, and electrophysiology.

Main Methods:

  • Review of recent scientific literature.
  • Integration of data from mouse genetic studies.
  • Analysis of neuroanatomical and electrophysiological findings.

Main Results:

  • Identification of specific cellular mechanisms involved in metabolic signaling.
  • Elucidation of neural circuits regulating feeding and energy balance.
  • Insights into the control of glucose homeostasis by metabolic signals.

Conclusions:

  • Advances in mouse genetics and neuroscience techniques have significantly improved our understanding of metabolic regulation.
  • Neural circuits and cellular mechanisms are key targets for future therapeutic strategies for metabolic diseases.