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Updated: May 10, 2026
12:26
Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay
Published on: May 3, 2018
New roles of cyclin D1
1Department of Cancer Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA. director@kimmelcancercenter.org
The American Journal of Pathology
|June 25, 2013
Summary
Cyclins, regulators of cell division, have newly discovered roles beyond cancer. Cyclin D1 also influences cell movement, DNA repair, and gene expression, revealing broader biological significance.
Area of Science:
- Molecular Biology
- Cell Biology
- Biochemistry
Background:
- Cyclins are key regulators of holoenzymes involved in cell phosphorylation.
- The established roles of cyclins in cell cycle and tumorigenesis are well-documented.
- Emerging evidence suggests novel functions for cyclins beyond cell cycle control.
Purpose of the Study:
- To review and describe the recently identified functions of cyclin D1.
- To elucidate the mechanisms underlying these new roles of cyclin D1.
- To highlight the expanded biological significance of cyclin D1.
Main Methods:
- Literature review of recent studies on cyclin D1.
- Analysis of experimental data on cyclin D1's non-canonical functions.
- Synthesis of information on molecular mechanisms.
Main Results:
- Cyclin D1 actively promotes cellular migration and invasion.
- It enhances angiogenesis and inhibits mitochondrial metabolism.
- Cyclin D1 regulates transcription factors, induces chromosomal instability, and impacts DNA repair.
- It also plays a role in feedback governing the noncoding genome.
Conclusions:
- Cyclin D1 exhibits diverse functions extending beyond its classical cell cycle role.
- These novel functions involve critical cellular processes including migration, metabolism, and genome regulation.
- Understanding these new roles is crucial for a comprehensive view of cyclin D1's biological impact.
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