Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 10, 2026

Translational Orthotopic Models of Glioblastoma Multiforme
07:37

Translational Orthotopic Models of Glioblastoma Multiforme

Published on: February 17, 2023

Anaplastic ependymoma with ependymoblastic multilayered rosettes.

Sumihito Nobusawa1, Aya Suzuki, Masaya Nagaishi

  • 1Department of Human Pathology, Gunma University Graduate School of Medicine, Gunma 371-8511, Japan.

Human Pathology
|June 25, 2013
PubMed
Summary

Anaplastic ependymoma (WHO grade III) can mimic ependymoblastoma histologically. This case highlights that true rosettes with multilayering tumor cells do not always indicate ependymoblastoma, even in aggressive gliomas.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Arterial calcification due to CD73 deficiency presenting with critical limb-threatening ischemia successfully treated with iliac endarterectomy and distal bypass.

Journal of vascular surgery cases and innovative techniques·2026
Same author

A multicenter randomized phase II/III trial of salvage treatment for refractory primary central nervous system lymphoma using tirabrutinib: JCOG2314 (ReSTART).

Japanese journal of clinical oncology·2026
Same author

Epstein-Barr virus-associated smooth muscle tumor of the liver after umbilical cord blood transplantation for acute myeloid leukemia.

Clinical journal of gastroenterology·2026
Same author

A Two-Dimensional Plot of Cell Aggregates and Their Largest Nuclei Distinguishes Benign From Malignant Pleural Effusion Cytology Specimens.

Cytopathology : official journal of the British Society for Clinical Cytology·2026
Same author

BEND2 Immunohistochemistry as a Useful Diagnostic Marker for Astroblastomas With BEND2 Fusion.

The American journal of surgical pathology·2026
Same author

A Case of Myxoid Glioneuronal Tumor in the Lateral Ventricle.

NMC case report journal·2026

Area of Science:

  • Neuro-oncology
  • Pathology
  • Molecular Diagnostics

Background:

  • Anaplastic ependymoma (WHO grade III) is a malignant glioma with distinct histological features.
  • Distinguishing it from ependymoblastoma is crucial for accurate diagnosis and treatment.

Observation:

  • An autopsy case presented a frontal lobe tumor with histological features resembling ependymoblastoma, including multilayered true rosettes.
  • This presentation differed from typical anaplastic ependymoma, which usually has fewer rosettes.

Findings:

  • Molecular and cytogenetic analyses confirmed the absence of 19q13.42 amplification, a known marker for ependymoblastoma.
  • The absence of this molecular hallmark supported the diagnosis of anaplastic ependymoma despite the unusual histology.
Keywords:
19q13.42Ependymoblastic rosettesEpendymoma

More Related Videos

Primary Orthotopic Glioma Xenografts Recapitulate Infiltrative Growth and Isocitrate Dehydrogenase I Mutation
09:43

Primary Orthotopic Glioma Xenografts Recapitulate Infiltrative Growth and Isocitrate Dehydrogenase I Mutation

Published on: January 14, 2014

Related Experiment Videos

Last Updated: May 10, 2026

Translational Orthotopic Models of Glioblastoma Multiforme
07:37

Translational Orthotopic Models of Glioblastoma Multiforme

Published on: February 17, 2023

Primary Orthotopic Glioma Xenografts Recapitulate Infiltrative Growth and Isocitrate Dehydrogenase I Mutation
09:43

Primary Orthotopic Glioma Xenografts Recapitulate Infiltrative Growth and Isocitrate Dehydrogenase I Mutation

Published on: January 14, 2014

Implications:

  • This case underscores the importance of integrating histological and molecular findings for accurate glioma classification.
  • It highlights potential diagnostic challenges in differentiating aggressive ependymoma subtypes.
  • Accurate diagnosis is critical for guiding appropriate therapeutic strategies in neuro-oncology.