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Updated: May 10, 2026

High-definition Fourier Transform Infrared (FT-IR) Spectroscopic Imaging of Human Tissue Sections towards Improving Pathology
Published on: January 21, 2015
Rapid FTIR chemical imaging: highlighting FPA detectors
Konrad M Dorling1, Matthew J Baker
1Centre for Materials Science, Division of Chemistry, School of Forensic and Investigative Sciences, University of Central Lancashire-UCLan, Preston PR1 2HE, UK. konrad@dorling.net
Abstract:
Fourier transform infrared (FTIR) spectroscopy is an established analytical technique that measures molecular bond vibrations via infrared absorption. The technique traditionally obtains single spectra from a sample, averaging the absorption information over a pre-determined aperture size. However, this averaging of information can be detrimental to pure biochemical analysis. The coupling of focal plane array (FPA) detectors to conventional FTIR systems and recent technical advances in FPA technology have allowed the concurrent rapid collection of thousands of infrared spectra over large areas of a sample, which has been particularly useful in tissue analysis. This novel technique presents a strong case for its use as a potential tool to aid in the clinic for disease diagnosis and assessment.
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