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Related Concept Videos

Imaging Studies IV: Magnetic Resonance Imaging01:27

Imaging Studies IV: Magnetic Resonance Imaging

Introduction:Magnetic Resonance Imaging, or MRI, can include a specialized imaging technique of the urinary system known as Magnetic Resonance Urography (MRU). This radiation-free technique uses strong magnetic fields and radio waves to produce detailed images with the help of a computer. MRU is particularly effective for visualizing fluid-filled structures like the kidneys, ureters, and bladder.Applications of MRI in the Genitourinary SystemKidneys and Ureters: MRI detects tumors, cysts,...
Imaging Studies I: Kidney, Ureter, and Bladder Studies01:28

Imaging Studies I: Kidney, Ureter, and Bladder Studies

Kidney, Ureter, and Bladder (KUB) StudiesKidney, Ureter, and Bladder (KUB) studies are standard diagnostic imaging procedures used to assess the anatomy of the urinary system. They are commonly utilized for patients experiencing abdominal pain or urinary symptoms. By using a simple X-ray of the abdomen, KUB studies can reveal structural and pathological abnormalities within the kidneys, ureters, and bladder. These studies are particularly valuable in diagnosing kidney stones, urinary...
Imaging Studies V: Intravenous Urography and Retrograde Pyelography01:22

Imaging Studies V: Intravenous Urography and Retrograde Pyelography

IntroductionIntravenous Urography (IVU) and Retrograde Pyelography (RP) are important diagnostic imaging techniques used to evaluate the urinary system. These methods help identify structural abnormalities, obstructions, and functional issues in the kidneys, ureters, and bladder. Both procedures use iodine-based contrast media to enhance the visibility of urinary tract structures on X-ray images, though they differ in their methods and indications.1. Intravenous Urography (IVU)Intravenous...

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Related Experiment Video

Updated: May 10, 2026

Use of MRI-ultrasound Fusion to Achieve Targeted Prostate Biopsy
09:11

Use of MRI-ultrasound Fusion to Achieve Targeted Prostate Biopsy

Published on: April 9, 2019

Boosting imaging defined dominant prostatic tumors: a systematic review.

Glenn Bauman1, Masoom Haider, Uulke A Van der Heide

  • 1Department of Oncology, London Health Sciences Centre and University of Western Ontario and Western University, Canada. glenn.bauman@lhsc.on.ca

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
|June 25, 2013
PubMed
Summary
This summary is machine-generated.

This systematic review found insufficient evidence to support differential radiation boosts to imaging-defined prostate gross tumor volumes (GTVs). Optimal techniques and efficacy remain elusive, pending results from ongoing trials.

Keywords:
BoostDILGTVMRIPETProstateSPECT

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Area of Science:

  • Radiation Oncology
  • Prostate Cancer Treatment
  • Clinical Evidence Synthesis

Background:

  • Prostate cancer recurrence post-radiotherapy is linked to dominant tumor foci.
  • Investigating differential boosting to imaging-defined gross tumor volumes (GTVs) is crucial for improving outcomes.

Purpose of the Study:

  • To systematically review clinical evidence supporting differential radiation boosts to imaging-defined GTVs in prostate cancer.
  • To evaluate the efficacy and optimal techniques for GTV boosts delivered via external beam or brachytherapy.

Main Methods:

  • A systematic review of clinical series reporting radiation boosts to imaging-defined GTVs was conducted.
  • Thirteen papers encompassing 11 unique patient series (833 patients) were identified and analyzed.

Main Results:

  • Significant variability existed in GTV definition, treatment methods, and boost doses (external beam: 8 Gy avg; brachytherapy: 150% avg).
  • Low reported toxicity rates may be attributed to modest boost doses, small volumes, and conservative dose constraints.
  • Heterogeneity in study designs and outcome reporting precluded definitive conclusions on efficacy.

Conclusions:

  • Evidence for differential boosts to intra-prostatic GTVs is inconclusive, and the approach is not standard of care.
  • Further research, including ongoing prospective randomized trials, is needed to establish optimal techniques and efficacy.
  • Consensus building and robust evidence generation are required to define the role of GTV-based differential prostate boosts.