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Updated: May 10, 2026

Establishment and Propagation of Human Retinoblastoma Tumors in Immune Deficient Mice

Establishment and Propagation of Human Retinoblastoma Tumors in Immune Deficient Mice

Published on: August 4, 2011

Retinoblastoma presenting with orbital cellulitis.

Jaydeep Walinjkar¹, S Krishnakumar, Lingam Gopal

¹Department of Vitreo-Retinal Services, Sankara Nethralaya, Nungambakkam, Chennai, Tamil Nadu, India.

Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus

|June 25, 2013

Summary

Pre-enucleation steroids effectively reduced inflammation in retinoblastoma patients with orbital cellulitis, aiding surgical management. This study highlights their benefit in advanced cases.

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Last Updated: May 10, 2026

Establishment and Propagation of Human Retinoblastoma Tumors in Immune Deficient Mice

Establishment and Propagation of Human Retinoblastoma Tumors in Immune Deficient Mice

Published on: August 4, 2011

Area of Science:

Ophthalmology
Pediatric Oncology
Oncology

Background:

Retinoblastoma, a common intraocular malignancy in children, can present with orbital cellulitis.
Orbital cellulitis in retinoblastoma often indicates advanced disease with significant inflammation.

Purpose of the Study:

To evaluate the efficacy of pre-enucleation systemic steroids in mitigating inflammation associated with retinoblastoma-induced orbital cellulitis.
To assess the impact of steroids on the surgical management of these complex cases.

Main Methods:

Retrospective review of retinoblastoma patients presenting with orbital cellulitis over three years.
Analysis of clinical, radiological, and histopathological data.
Assessment of outcomes in patients who received pre-enucleation systemic steroids.

Main Results:

14 cases of retinoblastoma-associated cellulitis were identified (5.39% of retinoblastoma cases).
Nine patients with orbital cellulitis and intraocular tumors occupying 80-100% of the globe were included.
Five patients receiving pre-enucleation steroids showed a prompt decrease in inflammation.

Conclusions:

Advanced, necrotic retinoblastoma with anterior segment involvement can mimic orbital cellulitis.
Pre-enucleation systemic steroids are beneficial in managing inflammation and facilitating surgical intervention for retinoblastoma presenting as orbital cellulitis.