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Liver Regeneration

Liver Regeneration

The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are large...

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Updated: May 10, 2026

A Novel Surgical Technique As a Foundation for In Vivo Partial Liver Engineering in Rat

A Novel Surgical Technique As a Foundation for In Vivo Partial Liver Engineering in Rat

Published on: October 6, 2018

Engineered liver for transplantation.

Basak E Uygun¹, Martin L Yarmush

¹Center for Engineering in Medicine, Massachusetts General Hospital, Harvard Medical School and Shriners Hospitals for Children in Boston, 51 Blossom Street, Boston, MA 02114, USA.

Current Opinion in Biotechnology

|June 25, 2013

Summary

This summary is machine-generated.

Whole liver engineering using decellularized organ scaffolds offers a promising solution to the donor organ shortage for liver transplantation. This approach retains the native circulatory network, enabling cell repopulation and potential for functional graft development.

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Last Updated: May 10, 2026

A Novel Surgical Technique As a Foundation for In Vivo Partial Liver Engineering in Rat

A Novel Surgical Technique As a Foundation for In Vivo Partial Liver Engineering in Rat

Published on: October 6, 2018

Generation of a Humanized Mouse Liver Using Human Hepatic Stem Cells

Generation of a Humanized Mouse Liver Using Human Hepatic Stem Cells

Published on: August 29, 2016

Three-Dimensional Collagen Matrix Scaffold Implantation as a Liver Regeneration Strategy

Three-Dimensional Collagen Matrix Scaffold Implantation as a Liver Regeneration Strategy

Published on: June 29, 2021

Area of Science:

Regenerative Medicine
Biomaterials Science
Transplantation Biology

Background:

End-stage liver failure necessitates transplantation, but donor organ scarcity is a major limitation.
Current liver tissue engineering strategies, including bottom-up and synthetic biomaterial approaches, have not yet yielded transplantable functional liver grafts.
A novel strategy utilizes whole organ scaffolds derived from decellularized native organs.

Purpose of the Study:

To review recent advancements in whole organ scaffold-based liver tissue engineering.
To discuss the challenges and future directions for creating functional, transplantable liver grafts using this approach.

Main Methods:

Perfusion decellularization of whole organs to create acellular scaffolds.
Retention of the native vascular network within the decellularized scaffold.
Repopulation of scaffolds with cells for potential graft development.

Main Results:

Decellularized whole organ scaffolds preserve the intricate circulatory architecture.
This preserved network facilitates cell seeding and integration.
The approach holds potential for generating vascularized liver constructs.

Conclusions:

Whole organ engineering via decellularization presents a promising avenue to overcome donor organ limitations in liver transplantation.
Challenges remain in achieving full functionality and clinical translation of these engineered grafts.
Further research is crucial to optimize cell sourcing, vascularization, and long-term graft performance.