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Published on: June 10, 2021
Synthesis and antimicrobial activity of imidazole and pyridine appended cholestane-based conjugates
Hong-Seok Kim1, Jyoti R Jadhav, Sung-Ji Jung
1Department of Applied Chemistry, Kyungpook National University, 80 University Road, Buk-gu, Daegu 702-701, Republic of Korea. kimhs@knu.ac.kr
Abstract:
A series of 3α-amino-5α-cholestane and 3α,7α-diamino-5α-cholestane derivatives containing imidazole and pyridine rings were synthesized by simple and effective reductive amination, and their in vitro activities against a range of Gram-positive and Gram-negative strains were evaluated. Most of the compound exhibited enhanced activity against MRSA pathogen. 3α,7α-Di(pyridylmethyl)amino-5α-cholestane 10 showed the highest potency in these series toward the Gram-positive bacteria, Staphylococcus epidermidis 887E, with the lowest MIC value of 1 μg/mL.
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