Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Regulation of Food Intake

Regulation of Food Intake

Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...

Regulation of Metabolism

Regulation of Metabolism

Cellular needs and conditions vary from cell to cell and change within individual cells over time. For example, the required enzymes and energetic demands of stomach cells are different from those of fat storage cells, skin cells, blood cells, and nerve cells. Furthermore, a digestive cell works much harder to process and break down nutrients during the time that closely follows a meal compared with many hours after a meal. As these cellular demands and conditions vary, so do the amounts and...

Adrenergic Receptors: β Subtype

Adrenergic Receptors: β Subtype

β-adrenoceptors have varied sensitivities towards adrenaline, noradrenaline, and isoprenaline. The order of agonist potency is as follows:
Isoprenaline > Adrenaline > Noradrenaline
Neurotransmitter binding to these receptors causes activation of adenylyl cyclase resulting in increased concentrations of cAMP and modulation of calcium ion channels within the cell. They are further classified into β1, β2, and β3 subtypes.
β1-adrenoceptors: β1-adrenoceptors have equal affinities for...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Patterns of X-linked inheritance: A new approach for the genome era.

Genetics in medicine : official journal of the American College of Medical Genetics·2025

Same author

Prognostication and Biomarker Potential of C26:0 Lysophosphatidylcholine in Adrenoleukodystrophy.

JAMA pediatrics·2025

Same author

Insights From Minnesota on Newborn Screening for Adrenoleukodystrophy: A 5-Year Update.

American journal of medical genetics. Part A·2025

Same author

Interactions between Lateral Hypothalamic Orexin and Dorsal Raphe Circuitry in Energy Balance.

Brain sciences·2024

Same author

Cost-Effectiveness of Newer Pharmacologic Treatments in Adults With Type 2 Diabetes: A Systematic Review of Cost-Effectiveness Studies for the American College of Physicians.

Annals of internal medicine·2024

Same author

Newer Pharmacologic Treatments in Adults With Type 2 Diabetes: A Systematic Review and Network Meta-analysis for the American College of Physicians.

Annals of internal medicine·2024

Search research articles

Related Experiment Video

Updated: May 10, 2026

Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis

Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis

Published on: June 3, 2016

Orexin modulation of adipose tissue.

Claudio E Perez-Leighton¹, Charles J Billington², Catherine M Kotz³

¹Veterans Health Care System, GRECC, One Veterans Drive, Minneapolis, MN 55417, USA; University of Minnesota, MN Obesity Center, 1334 Eckles Avenue, St Paul, MN 55108, USA; Center for Integrative Medicine and Innovative Sciences, Facultad de Medicina, Universidad Andres Bello, Echaurren 183, Santiago, 8370071, Chile.

Biochimica Et Biophysica Acta

|June 25, 2013

Summary

Orexins regulate energy balance and body weight. Lacking orexins in rodents increases adiposity due to reduced energy expenditure and physical activity, suggesting broader impacts on adipose tissue.

Keywords:

Adipose tissue Brain Energy expenditure Orexin

More Related Videos

Encapsulation Thermogenic Preadipocytes for Transplantation into Adipose Tissue Depots

Encapsulation Thermogenic Preadipocytes for Transplantation into Adipose Tissue Depots

Published on: June 2, 2015

Measurement of Basal and Forskolin-stimulated Lipolysis in Inguinal Adipose Fat Pads

Measurement of Basal and Forskolin-stimulated Lipolysis in Inguinal Adipose Fat Pads

Published on: July 21, 2017

Related Experiment Videos

Last Updated: May 10, 2026

Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis

Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis

Published on: June 3, 2016

Encapsulation Thermogenic Preadipocytes for Transplantation into Adipose Tissue Depots

Encapsulation Thermogenic Preadipocytes for Transplantation into Adipose Tissue Depots

Published on: June 2, 2015

Measurement of Basal and Forskolin-stimulated Lipolysis in Inguinal Adipose Fat Pads

Measurement of Basal and Forskolin-stimulated Lipolysis in Inguinal Adipose Fat Pads

Published on: July 21, 2017

Area of Science:

Neuroendocrinology
Metabolic Regulation

Background:

Orexins are neuropeptides crucial for central nervous system functions.
They play significant roles in regulating energy balance, obesity, and adipose tissue accumulation.
Rodents lacking orexins exhibit increased weight gain and adiposity.

Purpose of the Study:

To review the current understanding of how orexin peptides influence adipose tissue.
To explore the physiological effects of orexins on white and brown adipose tissues in energy balance.
To integrate orexin physiology with adipose tissue function in health and disease.

Main Methods:

Literature review of studies on orexins and adipose tissue.
Analysis of evidence from rodent models, particularly genetic knockouts.
Synthesis of research on neural influences on white and brown adipose tissues.

Main Results:

Orexin deficiency in rodents leads to increased adiposity, primarily via reduced energy expenditure and physical activity.
Evidence suggests additional mechanisms beyond reduced activity contribute to orexin-induced adiposity.
Orexin peptides and receptors are present in adipose tissue, but their specific functions are not well-defined.

Conclusions:

Orexins significantly impact energy balance and adipose tissue regulation.
Further research is needed to fully elucidate the neural control of adipose tissues by orexins.
Understanding orexin-adipose tissue interactions is vital for metabolic health and disease management.