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Atherosclerosis I: Introduction01:30

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Updated: May 10, 2026

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
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Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Published on: October 12, 2017

Aging affects high-density lipoprotein composition and function.

Michael Holzer1, Markus Trieb, Viktoria Konya

  • 1Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Austria.

Biochimica Et Biophysica Acta
|June 25, 2013
PubMed
Summary
This summary is machine-generated.

Aging significantly alters high-density lipoprotein (HDL) composition and function. These changes in HDL, a key factor in cardiovascular health, may increase the risk of heart disease in older adults.

Keywords:
Anti-oxidative activityCardiovascular diseaseParaoxonaseProteome

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Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
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Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
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Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

Published on: November 10, 2017

Area of Science:

  • Cardiovascular Science
  • Gerontology
  • Lipid Metabolism

Background:

  • Coronary heart disease is a leading cause of death, particularly in individuals over 65.
  • Age-related changes in high-density lipoprotein (HDL) composition and function are implicated in cardiovascular mortality.
  • The specific impact of advanced age on HDL characteristics remains incompletely understood.

Purpose of the Study:

  • To investigate the effects of advanced age on the composition and functionality of high-density lipoproteins (HDL).
  • To compare HDL from healthy young and elderly subjects to identify age-associated alterations.

Main Methods:

  • Isolation of HDL from healthy young and elderly individuals.
  • Assessment of HDL composition, including protein content and lipid profile.
  • Evaluation of HDL function, such as cellular cholesterol efflux/uptake, antioxidant properties, and paraoxonase activity.

Main Results:

  • HDL from elderly subjects showed increased levels of serum amyloid A and complement C3, with decreased apolipoprotein E.
  • Elderly HDL had reduced cholesterol and increased sphingomyelin content.
  • Functional deficits in elderly HDL included impaired antioxidant properties, lower paraoxonase 1 activity, and increased macrophage uptake, while cholesterol efflux remained unchanged.

Conclusions:

  • Aging alters HDL composition, characterized by changes in specific proteins and lipids.
  • These compositional changes lead to functional impairments in HDL, including reduced antioxidant capacity and altered cellular interactions.
  • The age-associated functional decline of HDL may contribute to the development and progression of cardiovascular disease.