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[The immunologic impact and adverse effects of simultaneous inoculation with DPT and BCG vaccines]
1Shanghai Hygiene and Anti-Epidemic Center.
Insights
Simultaneous vaccination with Diphtheria-Tetanus-Pertussis (DTP) and Bacillus Calmette-Guérin (BCG) vaccines is safe and effective in infants aged 3-7 months. Immunological responses and adverse effects were comparable to separate vaccinations, supporting combined DTP and BCG inoculation.
Area of Science:
- Pediatric Infectious Diseases
- Immunology
- Vaccinology
Background:
- Simultaneous administration of multiple vaccines is common in infant immunization schedules.
- The Diphtheria-Tetanus-Pertussis (DTP) and Bacillus Calmette-Guérin (BCG) vaccines are crucial for preventing serious childhood diseases.
- Understanding the immunological impact and safety of co-administering DTP and BCG is essential for optimizing vaccination strategies.
Purpose of the Study:
- To evaluate the immunological response and safety of simultaneous DTP and BCG vaccination in infants.
- To compare the antibody titers for pertussis and diphtheria, and the tuberculin skin test (TST) response after simultaneous versus separate DTP and BCG inoculations.
Main Methods:
- A randomized controlled trial involving infants aged 3-7 months allocated into three groups: simultaneous DTP-BCG, DTP alone, and BCG alone.
- Measurement of conglutinant antibodies against pertussis and diphtheria at specified intervals post-vaccination.
- Assessment of the tuberculin (OT) test positivity rate and mean induration diameter at three months post-vaccination.
Main Results:
- No statistically significant differences were observed in pertussis antibody titers, diphtheria antibody levels, or tuberculin skin test responses between the simultaneous DTP-BCG group and the respective DTP-alone or BCG-alone groups (P > 0.05).
- Conglutinant antibody titers for pertussis in the simultaneous group were 1:452 (1 month) and 1:192 (3 months); diphtheria antibody levels were 0.459 IU/ml (3 months).
- The OT test showed a 95% positive rate with a mean diameter of 10.4 mm in the simultaneous group, compared to 98% and 9.8 mm in the BCG-alone group.
Conclusions:
- Simultaneous inoculation of DTP and BCG vaccines is immunologically non-inferior to separate administration.
- The combined DTP-BCG vaccination strategy is safe, with no abnormal adverse effects reported across the study groups.
- These findings support the feasibility and safety of concurrent DTP and BCG vaccination in infants aged 3-7 months.
Abstract:
This article reported the impact and adverse effect in simultaneous inoculation of DPT and BCG. The infants whose age was from 3 to 7 month were allocated into three groups randomly. The conglutinant antibody against pertussis in experiment group was 1:452 in the first month and 1:192 in the third month after vaccination, the conglutinant antibody of diphtheria was 0.459 IU/ml in the third month. These in DPT alone group were 1:640, 1:140 and 0.639 IU/ml (P greater than 0.05). In experimental group, the positive rate of the OT test was 95% in the third month and the mean diameter of the node was 10.4 mm, these in BCG alone group were 98% and 9.8 mm (P greater than 0.05). There were no abnormal effect in three groups. The result indicated that DPT and BCG could be inoculated simultaneously.