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    Enzyme engineering combined with chemistry creates novel biocatalysts. A new whole-cell catalyst efficiently converts olefins into cyclopropanes, valuable synthetic intermediates.

    Area of Science:

    • Biocatalysis and synthetic chemistry
    • Enzyme engineering and metabolic pathway construction

    Background:

    • Enzyme engineering offers a powerful route to develop biocatalysts with enhanced performance and novel functions.
    • Integrating chemistry-based strategies into enzyme engineering expands the toolkit for designing bespoke biocatalysts.

    Discussion:

    • Development of a whole-cell catalyst for the conversion of olefins to cyclopropanes.
    • Cyclopropanes are key synthetic intermediates for constructing complex molecules.

    Key Insights:

    • Demonstrates the successful application of integrated chemistry and enzyme engineering for biocatalyst development.
    • Highlights the potential for creating efficient biocatalytic routes to valuable chemical compounds.

    Outlook:

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    • This approach paves the way for developing new biocatalysts for diverse chemical transformations.
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