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Augmenting transcranial direct current stimulation with (D)-cycloserine for depression: a pilot study.

Herng-Nieng Chan1, Angelo Alonzo, Donel M Martin

  • 1School of Psychiatry, University of New South Wales, Sydney, Australia. chan.herng.nieng@sgh.com.sg

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|June 25, 2013
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Combining D-Cycloserine with transcranial direct current stimulation (tDCS) did not improve depression treatment outcomes in this pilot study. The combination was well-tolerated but did not show enhanced antidepressant effects compared to tDCS alone.

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Pharmacology

Background:

  • Transcranial direct current stimulation (tDCS) is a noninvasive brain stimulation technique influencing cortical excitability.
  • Previous studies suggest tDCS efficacy in treating depression.
  • Enhancing tDCS effects with pharmacological agents could improve depression treatment outcomes.

Purpose of the Study:

  • To investigate if combining D-Cycloserine with prefrontal tDCS could enhance or prolong antidepressant effects.
  • To assess the safety and tolerability of this combined treatment approach.

Main Methods:

  • An open-label pilot study involving five depressed subjects who had previously undergone tDCS.
  • Subjects received 100-mg D-Cycloserine two hours prior to 20 sessions of anodal prefrontal tDCS (2 mA, 20 minutes).
  • Clinical response was measured using the Montgomery-Åsberg Depression Rating Scale (MADRS).

Main Results:

  • The combination of D-Cycloserine and tDCS did not yield greater improvements in MADRS scores compared to tDCS alone.
  • No significant additional adverse effects were reported during the study.

Conclusions:

  • Pretreatment with D-Cycloserine before tDCS was well-tolerated in depressed patients.
  • This combination did not enhance the antidepressant efficacy of anodal prefrontal tDCS in this pilot study.