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Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...

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Related Experiment Video

Updated: May 10, 2026

Rat Model of Adhesive Capsulitis of the Shoulder
04:46

Rat Model of Adhesive Capsulitis of the Shoulder

Published on: September 28, 2018

Refractory adhesive capsulitis under acitretin therapy.

Matthias Lahner1, Christoph von Schulze Pellengahr, Wolfram Teske

  • 1Department of Orthopaedic Surgery, Ruhr-University Bochum, 44797 Bochum, Germany. m.lahner@klinikum-bochum.de

Technology and Health Care : Official Journal of the European Society for Engineering and Medicine
|June 25, 2013
PubMed
Summary

Adhesive capsulitis (AC), a condition causing limited shoulder motion, may be triggered by acitretin therapy. Arthroscopic adhesiolysis offers an effective treatment for this frustrating condition.

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Area of Science:

  • Orthopedics
  • Dermatology
  • Rheumatology

Background:

  • Adhesive capsulitis (AC) presents with restricted active and passive shoulder joint mobility.
  • The precise etiology of AC is not fully understood, but various contributing factors are recognized.

Observation:

  • A case of AC potentially linked to Re-PUVA therapy (PUVA irradiation combined with acitretin) for cutaneous T-cell lymphoma (mycosis fungoides) is presented.
  • Acitretin, a retinoid, is commonly prescribed for disorders of cornification.

Findings:

  • Conservative treatments, including intraarticular steroid injections and physical therapy, were initially unsuccessful.
  • Arthroscopic juxtaglenoid capsulotomy and adhesiolysis resulted in significant improvement in shoulder joint mobility.

Implications:

  • Acitretin therapy should be evaluated as a potential trigger for adhesive capsulitis.
  • Thorough review of patient medication is crucial for identifying potential AC triggers.
  • Arthroscopic adhesiolysis demonstrates efficacy in managing adhesive capsulitis, particularly after conservative treatment failure.