Related Experiment Video
Updated: May 10, 2026

04:11
A Conditioned Place Preference Protocol for Measuring Incubation of Craving in Rats
Published on: November 6, 2018
Peak provoked craving after smoking cessation
Irene Pericot-Valverde1, Olaya García-Rodríguez, Mar Rus-Calafell
1University of Oviedo, Spain.
Studies in Health Technology and Informatics
|June 25, 2013
Summary
Peak provoked craving (PPC) significantly decreases after 24 hours of smoking abstinence. This reduction in highest craving levels persists, remaining significantly lower after 7 days of continuous abstinence.
Area of Science:
- Addiction research
- Psychology of craving
Background:
- Cue-induced craving is a key factor in smoking relapse.
- Peak provoked craving (PPC) offers an alternative measure of craving intensity.
- The impact of abstinence on PPC in smokers requires further investigation.
Purpose of the Study:
- To evaluate the effect of smoking abstinence on Peak Provoked Craving (PPC).
- To determine if continuous abstinence alters PPC levels in smokers.
Main Methods:
- Assessing PPC in smokers undergoing abstinence.
- Comparing PPC levels at different abstinence durations (24 hours and 7 days).
Main Results:
- A significant reduction in PPC was observed 24 hours post-abstinence.
- Craving levels, measured by PPC, remained significantly lower at the 7-day abstinence mark.
Conclusions:
- Smoking abstinence effectively reduces Peak Provoked Craving.
- PPC is a sensitive measure that reflects sustained reductions in craving intensity during early abstinence.
Related Concept Videos
Drug Dependence
Medications are typically administered to achieve therapeutic effects. Some drugs can modify an individual's mood and perception, frequently resulting in various enjoyable experiences. However, this can result in drug dependency, a condition marked by continuous drug use despite potential negative consequences. Drug dependency primarily falls into two categories: psychological and physical dependence. Psychological dependence occurs when the pleasurable feelings induced by the drug...
Chemotherapy-Induced Nausea and Vomiting: Cannabinoids
Tetrahydrocannabinol (THC) is a phytocannabinoid that primarily interacts with the CB1 receptor, a type of G protein-coupled receptor (GPCR) predominantly in and around the chemoreceptor trigger zone (CTZ) and emetic center. THC also blocks the serotonin receptor activity in the dorsal vagal complex (DVC) by inhibiting serotonin release. THC exerts its anti-emetic effects through these interactions, which are beneficial for patients undergoing chemotherapy.
Two synthetic agonists of THC,...
Two synthetic agonists of THC,...
Drugs Acting on Autonomic Ganglia: Stimulants
Ganglionic stimulants activate NM nicotinic receptors in autonomic ganglia, falling into two categories: nicotine mimetics [e.g., lobeline, dimethylpiperazine, tetramethylammonium] and muscarinic receptor agonists [e.g., muscarine, methacholine]. The first category's action is rapid and blocked by nicotinic receptor antagonists, while the second category's action is delayed and blocked by atropine-like agents. Nicotine, an alkaloid, affects the heart rate by stimulating sympathetic or...
Stimulants
Stimulants are substances that enhance neural activity and elevate dopamine levels in the brain, leading to their highly addictive nature. These drugs include cocaine, amphetamines, MDMA, caffeine, and nicotine, each with distinct mechanisms of action and varied health implications.
Cocaine can be administered via snorting, injection, or smoking. It primarily functions by blocking the reuptake of dopamine, resulting in a euphoric high characterized by an intense sensation of happiness and...
Cocaine can be administered via snorting, injection, or smoking. It primarily functions by blocking the reuptake of dopamine, resulting in a euphoric high characterized by an intense sensation of happiness and...
CNS Depressants: Alcohol and Nicotine
Ethanol, a clear colorless alcohol, has been consumed by humans for millennia, but its effects on the body are far from benign. At lower doses, it induces decreased inhibitions and loquaciousness, leading to its social appeal. However, it can cause severe consequences at higher doses, such as coma and respiratory depression, due to its zero-order elimination kinetics. Chronic ethanol abuse wreaks havoc on multiple organ systems, particularly the CNS and the liver. Abrupt cessation of ethanol...
Drug Abuse and Addiction: Pharmacological Phenomena
Drug dependence, abuse, and addiction are complex phenomena that can precipitate various abnormal states. Physical dependence refers to a state of pharmacological adaptation to a drug. This adaptation often results in tolerance—a reduced response to the drug after repeated administrations. When the drug use is abruptly stopped, withdrawal symptoms occur due to the body's need to readjust from the pharmacologically induced imbalance. However, tolerance and withdrawal symptoms do not necessarily...
