Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Myasthenia Gravis: Overview and Treatment

Myasthenia Gravis: Overview and Treatment

Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which leads...

Myasthenia Gravis: Diagnostic Tests

Myasthenia Gravis: Diagnostic Tests

Myasthenia gravis is an autoimmune condition affecting neuromuscular transmission, causing generalized weakness in skeletal muscles. Initial diagnoses rely on patients' signs, symptoms, and medical history. The challenge lies in distinguishing myasthenia from other muscular dystrophies. An important diagnostic feature is the significant improvement of symptoms after administering anticholinesterase inhibitors.
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Nail unit squamous cell carcinoma: A multicenter, retrospective study of the clinical and morphologic characteristics of 261 patients.

Journal of the American Academy of Dermatology·2026

Same author

Picosecond 755-nm alexandrite laser for labial lentigines in Peutz-Jeghers syndrome: A procedural case report.

JAAD case reports·2026

Same author

Type IV pityriasis rubra pilaris treated with ixekizumab.

Anais brasileiros de dermatologia·2026

Same author

Multicentric Granular Cell Tumor With Uncommon Dermoscopic Features.

Dermatology practical & conceptual·2025

Same author

Health Education Campaign to Improve Malaria Knowledge, Prevention, and Treatment Behaviors in Rural East Nusa Tenggara Province, Indonesia: Protocol for a Cluster-Assigned Quasi-Experimental Study.

JMIR research protocols·2025

Same author

Novel Insights Malalignment or Retronychia: Which Comes First?

Skin appendage disorders·2025

Same journal

Exuberant cutaneous lymphoepithelioma-like carcinoma: clinicopathological correlation in an aggressive case<sup>⋆</sup>.

Anais brasileiros de dermatologia·2026

Same journal

Tumor-like periungual cutaneous sporotrichosis in an endemic area.

Anais brasileiros de dermatologia·2026

Same journal

The skin microbiome: from historical ecology to therapeutic frontiers.

Anais brasileiros de dermatologia·2026

Same journal

Donovanosis - A rare, sexually transmitted infection that the world has not yet eradicated.

Anais brasileiros de dermatologia·2026

Same journal

The intergluteal cleft lesion in hidradenitis suppurativa: clinical characteristics and potential clinical implications.

Anais brasileiros de dermatologia·2026

Same journal

Skin cancer and actinic keratosis in people with albinism: a systematic review and meta-analysis.

Anais brasileiros de dermatologia·2026

See all related articles

Search research articles

Related Experiment Video

Updated: May 10, 2026

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

Argyria -- case report.

André Lencastre¹, Maria Lobo, Alexandre João

¹Dermatology Service of the Santo Antonio dos Capuchos Hospital – Central Lisbon Hospital Center (E.P.E) – Lisbon, Portugal. lencastre.derm@gmail.com

Anais Brasileiros De Dermatologia

|June 25, 2013

Summary

This summary is machine-generated.

A 70-year-old man developed Argyria, a grey skin pigmentation, after using intranasal silver vitellinate for five years. Despite regulations, unregulated silver products pose a risk for new cases of silver poisoning.

More Related Videos

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains

Published on: June 3, 2020

Related Experiment Videos

Last Updated: May 10, 2026

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains

Published on: June 3, 2020

Area of Science:

Dermatology
Toxicology

Background:

Argyria is a rare, irreversible skin discoloration caused by silver deposition.
Historically, silver compounds were used medically but are now largely restricted due to toxicity.
The case highlights the continued availability of unregulated silver products.

Observation:

A 70-year-old male presented with asymptomatic, widespread grey skin and nail pigmentation.
The patient reported a 5-year history of intranasal application of 10% Silver Vitellinate.
Clinical diagnosis was confirmed by skin biopsy and histological examination.

Findings:

Histopathology confirmed Argyria, consistent with chronic silver exposure.
The patient's symptoms developed over five years of intranasal silver vitellinate use.
This case underscores the persistence of silver-related dermatological issues.

Implications:

Unregulated silver colloids and salts sold as supplements or alternative medicines pose a public health risk.
Healthcare providers should be vigilant for Argyria in patients using such products.
Regulatory oversight is crucial to prevent emerging cases of silver poisoning.